The challenges and promises of allogeneic mesenchymal stem cells for use as a cell-based therapy.
The challenges and promises of allogeneic mesenchymal stem cells for use as a cell-based therapy.
复制标题
同种异体间充质干细胞用作细胞疗法的挑战和前景
DOI：
10.1186/s13287-015-0240-9
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发表时间：
2015-12-01
影响因子：
7.5
通讯作者：
Hu D
中科院分区：
文献类型：
--
作者：
Zhang J;Huang X;Wang H;Liu X;Zhang T;Wang Y;Hu D
间充质干细胞（MSCs）因其免疫抑制和组织修复特性，是多种炎性疾病细胞治疗的理想选择。此外，与其他细胞类型相比，其免疫抑制特性和低免疫原性有助于减少或减弱同种异体间充质干细胞植入所引发的免疫反应。因此，同种异体间充质干细胞植入可能是一种有前景的细胞治疗方法。在本综述中，我们首先总结了同种异体间充质干细胞在治疗应用中的独特优势。其次，我们批判性地分析了影响其治疗效果的因素，包括给药途径、检测时间点、疾病模型、间充质干细胞在体内的分化以及间充质干细胞给药的时间和剂量。最后，讨论了同种异体间充质干细胞应用的当前方法。总之，同种异体间充质干细胞由于其低免疫原性以及免疫抑制和组织修复能力，是一种有前景的选择。在将间充质干细胞用作炎性疾病的细胞治疗以及组织修复时，还需要进一步研究以提高其一致性和疗效。
Mesenchymal stem cells (MSCs) are ideal for cell-based therapy in various inflammatory diseases because of their immunosuppressive and tissue repair properties. Moreover, their immunosuppressive properties and low immunogenicity contribute to a reduced or weakened immune response elicited by the implantation of allogeneic MSCs compared with other cell types. Therefore, implantation of allogeneic MSCs may be a promising cell-based therapy. In this review, we first summarize the unique advantages of allogeneic MSCs for therapeutic applications. Second, we critically analyze the factors influencing their therapeutic effects, including administration routes, detection time-points, disease models, differentiation of MSCs in vivo, and timing and dosage of MSC administration. Finally, current approaches to allogeneic MSC application are discussed. In conclusion, allogeneic MSCs are a promising option because of their low immunogenicity and immunosuppressive and tissue repair capabilities. Further investigations are needed to enhance the consistency and efficacy of MSCs when used as a cell-based therapy in inflammatory diseases as well as for tissue repair.