Disease severity of respiratory syncytial virus (RSV) infection correlate to a novel set of five amino acid substitutions in the RSV attachment glycoprotein (G) in China
Disease severity of respiratory syncytial virus (RSV) infection correlate to a novel set of five amino acid substitutions in the RSV attachment glycoprotein (G) in China
复制标题
中国呼吸道合胞病毒 (RSV) 感染的疾病严重程度与 RSV 附着糖蛋白 (G) 中一组新的五个氨基酸取代相关
DOI：
10.1016/j.virusres.2020.197937
复制
发表时间：
2020-05-01
期刊：
影响因子：
5
通讯作者：
Li, Hongjian
中科院分区：
文献类型：
--
作者：
Li, Wanwei;Wang, Yanlan;Li, Hongjian
人呼吸道合胞病毒（RSV）是婴幼儿急性呼吸道疾病的主要病毒之一。我们对中国广州地区住院患儿进行了RSV的分子流行病学分析。系统发育分析和贝叶斯分析表明，ON1基因型是本研究中唯一的A亚组病毒。有趣的是，大多数广州ON1菌株形成了一个支持性很好的簇，这些菌株共享一组以前从未阐明过的新的五个氨基酸取代。此外，使用严重程度评分系统评估疾病严重程度。与其他RSV A阳性患者相比，携带新型RSV A毒株的患者呼吸道症状较轻。总之，在中国发现了一组特定的五个氨基酸取代，进一步的分析表明，疾病的严重程度与这些改变有关。这些发现将为RSV的致病机制和疫苗研制提供有价值的信息。
Human respiratory syncytial virus (RSV) is one of the major viruses of acute respiratory tract disease among infants and young children. We performed molecular epidemiology analysis of RSV among inpatient children in Guangzhou, China. Phylogenetic and Bayesian analysis showed that genotype ON1 was the only subgroup A virus in this study. Interestingly, the majority of Guangzhou ON1 strains formed a well-supported cluster, and these strains shared a novel set of five amino acid substitutions that never illustrated before. Furthermore, the degree of disease severity was assessed using a severity scoring system. The patients carrying the novel RSV A strain were associated with milder respiratory symptoms compared to other RSV A positives. In conclusion, a specific set of five amino acid substitutions was found in China and further analysis showed that disease severity was associated with these alterations. These findings will provide valuable information for the pathogenic mechanism and vaccine development of RSV.