Cancer outcomes research and the arenas of application.
Cancer outcomes research and the arenas of application.
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DOI：
10.1093/jncimonographs/lgh038
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发表时间：
2004-01-01
期刊：
影响因子：
--
通讯作者：
Hiatt, Robert A
中科院分区：
文献类型：
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作者：
Lipscomb, Joseph;Donaldson, Molla S;Hiatt, Robert A
2004年，美国估计将有150万人被诊断出患有癌症；约56万人将死于癌症；超过 950 万人将接受治愈性治疗，应对进展性疾病，或在成功治疗后摆脱癌症 (1)。但许多幸存者仍然感受到诊断和治疗带来的余震和下游副作用，许多人担心病情复发。美国国家癌症研究所 (NCI) 以及世界各地的癌症机构和组织正在通过各种举措、计划和项目，在减少癌症造成的痛苦和死亡方面取得实质性进展。在 NCI，这些努力强调了基础和应用科学发现、有希望的干预措施的开发和测试以及提供优质护理以预防、检测和治疗癌症以及延长癌症幸存者的生活长度和质量的共同重要性 (2)。因此，对于各级决策者来说，至关重要的是要深入了解如何有效地应用发现和开发的成果，以减少痛苦和死亡的方式加强癌症护理服务。对此类决策相关信息的科学追求是癌症结果研究的核心业务。本专着的总体目标是对癌症结果研究中的同行评审文献进行基于实证的回顾和评估。目的是确定最近的重要贡献以及在将科学合理的信息应用于癌症护理决策方面仍然存在的挑战。
In 2004, an estimated 1.5 million persons in the United States will be diagnosed with cancer; about 560000 will die from cancer; and more than 9.5 million will be undergoing curative treatment, coping with progressive disease, or living free of cancer after successful therapy (1). But many of these survivors still feel the aftershocks and downstream side effects arising from diagnosis and treatment, and many are fearful of recurrence. Substantial progress in reducing the suffering and death caused by cancer is being pursued by the National Cancer Institute (NCI) and cancer agencies and organizations worldwide through a variety of initiatives, programs, and projects. At the NCI, these efforts emphasize the joint importance of basic and applied scientific discovery, the development and testing of promising interventions, and the delivery of quality care to prevent, detect, and treat cancer and to improve the length and quality of life of cancer survivors (2). It is therefore vital for decision makers, at all levels, to have a firm understanding of just how effectively the fruits of discovery and development are being applied to enhance cancer care delivery in ways that reduce suffering and death. The scientific pursuit of such decision-relevant information is the central business of cancer outcomes research. The overall aim of this Monograph is to provide an empirically grounded review and evaluation of the peer-reviewed literature in cancer outcomes research. The intent is to identify both important recent contributions and the challenges that remain in bringing scientifically sound information to bear in cancer care decision making.