Inflammation and sleep in healthy individuals
Inflammation and sleep in healthy individuals
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DOI：
10.1093/sleep/30.6.729
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发表时间：
2007-06-01
期刊：
影响因子：
5.6
通讯作者：
Dimsdale, Joel E.
中科院分区：
文献类型：
--
作者：
Mills, Paul J.;von Kaenel, Roland;Dimsdale, Joel E.
研究目的：炎症在睡眠障碍患者中相对常见，并与睡眠质量相关。本研究的目的是检查炎症是否与健康个体的睡眠质量相关。设计与设置：在一个综合临床研究中心进行的观察性研究。参与者：本研究描述了124名无睡眠障碍的非洲裔美国人和高加索裔美国人女性和男性的炎症和多导睡眠图验证的睡眠。测量和结果：测定了已知在睡眠障碍和心血管疾病中升高的3种炎症标志物和/或介质的循环水平（白细胞介素-6 [IL-6]、内皮素-1 [ET-1]、可溶性细胞间粘附分子-1 [sICAM-1]）。睡眠的特点是多导睡眠图。多元线性回归分析显示，年龄的增长、男性性别和非裔美国人种族与睡眠质量较差独立相关。在控制这些变量后，较高水平的ET-1与较长的睡眠潜伏期独立相关（P
Study Objectives: Inflammation is relatively common in individuals with a sleep disorder and is associated with quality of sleep. The purpose of this study was to examine whether inflammation is associated with quality of sleep in healthy individuals.Design & Setting: Observational study in a General Clinical Research Center.Participants: This study characterized inflammation and polysomnographically verified sleep in 124 African American and Caucasian American women and men without a sleep disorder.Measurements and Results: Circulating levels of 3 markers and/or mediators of inflammation known to be elevated in sleep disorders and in cardiovascular disease were determined (interleukin-6 [IL-6] endothelin-1 [ET-1], soluble intercellular adhesion molecule-1 [sICAM-1]). Sleep was characterized by polysomnography. Multiple linear regression analyses showed that increasing age, male sex, and African American ethnicity were independently associated with poorer sleep. After controlling for these variables, higher levels of ET-1 were independently associated with greater sleep latency (P