Central injection of endomorphin-2, but not endomorphin-1, increases food intake in chicks via μ1-opioid receptors
Central injection of endomorphin-2, but not endomorphin-1, increases food intake in chicks via μ1-opioid receptors
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DOI：
10.2141/jpsa.44.205
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发表时间：
2007-04-01
影响因子：
1.5
通讯作者：
Izumi, Tomofumi
中科院分区：
文献类型：
--
作者：
Bungo, Takashi;Dodo, Koh-Ichi;Izumi, Tomofumi
内源性四肽内吗啡肽-1和-2是哺乳动物中有效的选择性μ阿片受体激动剂。本研究旨在阐明中枢注射内吗啡肽是否能增强雏鸡的摄食行为，并探讨其与μ（1）阿片受体的相互作用。结果表明，侧脑室注射10- 30 nmol内吗啡肽-2（endomorphin-2），在注射后60分钟内，能显著刺激雏鸡的摄食。然而，同样剂量的内吗啡肽-1注射ICV对摄食行为没有显著影响。μ（1）-阿片受体拮抗剂纳洛嗪可显着减弱内吗啡肽-2的增食欲作用。这些结果表明，内吗啡肽-2，而不是内吗啡肽-1，通过μ（1）-阿片受体进入鸡脑产生食欲的影响。
The endogenous tetrapeptides endomorphin-1 and -2 are potent, selective mu-opioid receptor agonists in mammals. The present study was done to elucidate whether central injection of endomorphins enhances feeding behavior in chicks, and to investigate the interaction with the mu(1)-opioid receptor. We found that the intracerebroventricular injection of endomorphin-2 (10-30nmol) significantly stimulated food intake in neonatal chicks during the 60-min period postinjection. However, the same doses of endomorphin-1 injected with ICV had no significant effects on feeding behavior. The orexigenic effect of endomorphin-2 was significantly attenuated by they mu(1)-opioid receptor antagonist naloxonazine. These results indicate that the administration of endomorphin-2, but not endomorphin-1, into the chick brain produces the orexigenic effect through the mu(1)-opioid receptor.