The development of sex differences in the locus coeruleus of the rat
The development of sex differences in the locus coeruleus of the rat
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DOI：
10.1016/s0361-9230(01)00540-8
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发表时间：
2001-09-01
影响因子：
3.8
通讯作者：
Guillamón, A
中科院分区：
文献类型：
--
作者：
Pinos, H;Collado, P;Guillamón, A
本文研究了蓝斑(LC)内性别差异的发育。LC是一种性二态结构，其中女性比男性表现出更大的体积和更多的神经元数量。雄性和雌性Wistar大鼠分别于出生前16天和20天以及出生后1、3、7、15、35、45、60和90天处死。雄性和雌性大鼠的神经元数量在出生后持续增加，雄性大鼠在P45岁时停止，雌性大鼠在P60岁时停止。这些发现指出，雄性和雌性大鼠存在不同的发育模式，并可能表明，性别差异可能是因为在青春期后，两性之间存在神经发生的不同时期。(C)2001年爱思唯尔科学公司。
Development of sex differences in the locus coeruleus (LC) is investigated. The LC is a sexually dimorphic structure in which the female manifests a larger volume and greater number of neurons than do males. Male and female Wistar rats were sacrificed on prenatal days (E) 16 and 20 and postnatally (P) on days 1, 3, 7, 15, 35, 45, 60, and 90. Male and female rats show a continuous increase in the number of neurons after birth that stops in the males by P45 and in females by P60. These findings point out the existence of different patterns of development in male and female rats and may suggest that sex differences could be established because of the existence of a differential period of neurogenesis in both sexes in the postpuberal period. (C) 2001 Elsevier Science Inc.