The inhibitory effect of miRNA-1 on ET-1 gene expression
The inhibitory effect of miRNA-1 on ET-1 gene expression
复制标题
miRNA-1对ET-1基因表达的抑制作用
DOI：
10.1016/j.febslet.2012.02.044
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发表时间：
2012-04-05
期刊：
影响因子：
3.5
通讯作者：
Ren, An-Jing
中科院分区：
文献类型：
--
作者：
Li, Dong;He, Bin;Ren, An-Jing
There is a close correlation between endothelin-1 (ET-1) and microRNA-1 (miRNA-1) expression in the heart, but whether ET-1 expression is regulated by miRNA-1 warrants further research. Our results revealed multiple clues suggesting that miRNA-1 may participate in inhibiting ET-1 gene expression. The inhibitory effect of miRNA-1 on recombinant luciferase reporter gene was mediated by the target sequence at the 127th nucleotide on ET-1 3'UTR. We further confirmed that miRNA-1 could inhibit endogenous ET-1 gene expression at the post-transcriptional level. Our study provides a new perspective on the regulatory mechanism of ET-1 gene. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
