Encoding of action by the Purkinje cells of the cerebellum.
Encoding of action by the Purkinje cells of the cerebellum.
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DOI：
10.1038/nature15693
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发表时间：
2015-10-15
期刊：
影响因子：
64.8
通讯作者：
Shadmehr R
中科院分区：
文献类型：
--
作者：
Herzfeld DJ;Kojima Y;Soetedjo R;Shadmehr R
准确的眼睛运动的执行关键取决于小脑，这表明浦肯野细胞（P细胞）可以预测眼睛的运动。然而，这种编码仍然是一个长期存在的难题：P细胞几乎没有表现出一致的调制方面的扫视幅度或方向，关键是，他们的放电持续时间比持续时间的扫视。在这里，我们分析了行为猴子眼蚓部的P细胞放电，发现在扫视过程中增加或减少其活动的神经元。我们估计这两个群体的综合效应，通过他们的投影在尾顶核（cFN），并揭示了一个简单的尖峰人口的反应，精确地预测了眼睛的实时运动。当我们根据每个细胞的复杂尖峰方向调谐来组织P细胞时，简单尖峰群体响应通过增益场倍增地预测扫视的实时速度和方向。这表明，小脑通过P细胞对单个核神经元的组合输入来预测扫视期间眼睛的实时运动。如果投射到核神经元上的P细胞不是随机选择的，而是共享一个共同的复杂尖峰特性，那么简单尖峰的增益场编码就会出现。
Execution of accurate eye movements depends critically on the cerebellum, suggesting that Purkinje cells (P-cells) may predict motion of the eye. Yet, this encoding has remained a long-standing puzzle: P-cells show little consistent modulation with respect to saccade amplitude or direction, and critically, their discharge lasts longer than duration of a saccade. Here, we analyzed P-cell discharge in the oculomotor vermis of behaving monkeys and found neurons that increased or decreased their activity during saccades. We estimated the combined effect of these two populations via their projections on the caudal fastigial nucleus (cFN) and uncovered a simple-spike population response that precisely predicted the real-time motion of the eye. When we organized the P-cells according to each cell's complex-spike directional tuning, the simple-spike population response predicted both the real-time speed and direction of saccade multiplicatively via a gain-field. This suggests that the cerebellum predicts the real-time motion of the eye during saccades via the combined inputs of P-cells onto individual nucleus neurons. A gain-field encoding of simple spikes emerges if the P-cells that project onto a nucleus neuron are not selected at random, but share a common complex-spike property.