Methamphetamine Use During Pregnancy Maternal and Neonatal Implications
Methamphetamine Use During Pregnancy Maternal and Neonatal Implications
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DOI：
10.1097/aog.0b013e3181e67094
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发表时间：
2010-08-01
影响因子：
7.2
通讯作者：
Kim, Matthew J.
中科院分区：
文献类型：
--
作者：
Good, Meadow M.;Solt, Ido;Kim, Matthew J.
目的：报告的人口统计学特征和临床发病率的甲基苯丙胺暴露的妊娠与对照组患者在三级保健，城市，学术medical center.METHODS：单网站图表审查2000年至2006年进行了比较。使用国际疾病分类第9版代码648.3x来识别潜在的研究参与者。具体的入选标准需要甲基苯丙胺使用的阳性尿液药物筛查或患者在妊娠期间使用甲基苯丙胺的声明。从276名患者的数据进行比较，然后在同一时期的各种人口统计学因素和围产期outcomes.RESULTS的一般产科人口的34,055：2000年和2006年之间确定了273例活产负责276例患者。与甲基苯丙胺使用显著相关的因素是年龄小于20岁（9%甲基苯丙胺，对照组患者为16%），非西班牙裔白色种族（55%对71%），已婚（12%比46%），早产（52%对17%），低Apgar评分（6%对1-2%），剖宫产（29%对23%），新生儿死亡率（4%对1%）。此外，产妇的人口统计学特征表明，这些妇女更有可能失业，使用其他滥用物质，并有较高的家庭暴力和通过率相比，控制population.CONCLUSION：甲基苯丙胺在怀孕期间使用是复杂的更病态的产妇和新生儿的结果相比，一般产科人口。由于本研究中的患者在人口统计学上有各种不同的方式，因此尝试早期识别这些患者并进行干预以改善妊娠相关结局似乎是可能的，也是必要的。
OBJECTIVE: To report the demographic characteristics and clinical morbidity of methamphetamine-exposed pregnancies compared with control patients in a tertiary care, urban, academic medical center.METHODS: A single-site chart review from 2000 to 2006 was conducted. International Classification of Diseases, 9th Revision code 648.3x was used to identify potential study participants. Specific inclusion criteria required either a positive urine drug screen for methamphetamine use or by patient statement of methamphetamine use during pregnancy. Data from 276 identified patients were then compared with the 34,055 in the general obstetric population during the same period for various demographic factors and perinatal outcomes.RESULTS: Two hundred seventy-six patients responsible for 273 live births were identified between 2000 and 2006. Factors that were significantly associated with methamphetamine use were age younger than 20 years (9% methamphetamine compared with 16% control patients), non-Hispanic white ethnicity (55% compared with 71%), married (12% compared with 46%), preterm delivery (52% compared with 17%), low Apgar scores (6% compared with 1-2%), cesarean delivery (29% compared with 23%), and neonatal mortality (4% compared with 1%). Additionally, the maternal demographic characteristics suggested that these women were more likely to be unemployed, use other abusive substances, and have higher rates of domestic violence and adoption when compared with the control population.CONCLUSION: Methamphetamine use in pregnancy is complicated by more morbid maternal and neonatal outcomes when compared with the general obstetric population. Because the patients in this study were in a variety of ways demographically distinct, attempts to identify these patients early and intervene in an effort to improve pregnancy-related outcomes appears possible and warranted.