A Genome-wide association study identified HLA-C associated with the effectiveness of methotrexate for psoriasis treatment
A Genome-wide association study identified HLA-C associated with the effectiveness of methotrexate for psoriasis treatment
复制标题
一项全基因组关联研究发现 HLA-C 与甲氨蝶呤治疗银屑病的有效性相关
DOI：
10.1111/jdv.17544
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发表时间：
2021
影响因子：
9.2
通讯作者：
Zhang X.
中科院分区：
文献类型：
--
作者：
Zhang Y.;Ding X.;Meng Z.;Chen M.;Zheng X.;Cai M.;Wu J.;Chang Y.;Zhang Q.;Jin L.;Qian D.;Li X.;Wu M.;Yan K.;Lu Y.;Zhang X.
摘要张医生、丁医生、孟医生、陈医生、郑医生、蔡医生、吴医生、常医生、张医生、金医生、钱医生、李医生、吴医生、严医生、卢医生和张医生没有任何需要披露的信息。一项全基因组关联研究确定了HLA-C与甲氨蝶呤治疗银屑病的有效性相关。甲氨蝶呤（MTX）是一种叶酸还原酶抑制剂，被规定为银屑病患者的一线全身治疗。1-2尽管MTX的治疗功效已得到很好的证明，但患者对MTX治疗的反应表现出很大的异质性，并且MTX在特定患者中的功效是不可预测的。[摘自文章]
Abstract Dr. Zhang, Dr. Ding, Dr. Meng, Dr. Chen, Dr. Zheng, Dr. Cai, Dr. Wu, Dr. Chang, Dr. Zhang, Dr. Jin, Dr. Qian, Dr. Li, Dr. Wu, Dr. Yan, Dr. Lu and Dr. Zhang have nothing to disclose. A Genome-wide association study identified HLA-C associated with the effectiveness of methotrexate for psoriasis treatment Methotrexate (MTX), a folic acid reductase inhibitor, is prescribed as the first-line systemic treatment for patients with psoriasis. 1-2 Although the therapeutic efficacy of MTX has been well demonstrated, patients show substantial heterogeneity in their response to MTX therapies, and the efficacy of MTX in a given patient is unpredictable.[Extracted from the article]