Variable geographic distribution of Blastocystis subtypes and its potential implications
Variable geographic distribution of Blastocystis subtypes and its potential implications
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DOI：
10.1016/j.actatropica.2012.12.011
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发表时间：
2013-04-01
期刊：
影响因子：
2.7
通讯作者：
Clark, C. Graham
中科院分区：
文献类型：
--
作者：
Alfellani, Mohammed A.;Stensvold, C. Rune;Clark, C. Graham
芽囊原虫是一种常见的肠道微真核生物，在人类和非人类宿主中发现，并且已知其遗传非常多样。它已被分为许多亚型（ST），其中9个已在人类中确定的日期。在过去几年中开始出现ST流行率调查，但迄今为止，除埃及和坦桑尼亚外，没有任何非洲国家的数据。在这项研究中，我们确定了利比亚，利比里亚和尼日利亚人群中囊胚STs的患病率，并扩展了英国的数据集。本研究共确定了356种囊胚ST，271种来自英国，38种来自利比亚，25种来自利比里亚，22种来自尼日利亚。SSU rRNA基因序列显示，人类已知的9种ST中有8种存在，但各国之间的频率不同。ST1是利比亚和尼日利亚最常见的ST，而ST3在其他两个国家显示出最高的频率，事实上，在世界各地的大多数人群中都是如此。利比亚没有ST 4，尼日利亚没有ST 2，而在三个非洲人群中均未检测到ST 5、ST 6、ST 8或ST 9感染。从这项调查和其他调查中得出的结果表明，不同人群的ST患病率存在显著差异。这种多样性的一些可能的原因和影响进行了讨论。(C)2012爱思唯尔有限公司版权所有。
Blastocystis is a common intestinal micro-eukaryote found in both humans and non-human hosts and known to be genetically very diverse. It has been divided into numerous subtypes (STs), nine of which have been identified in humans to date. Surveys of ST prevalence have started to emerge over the past few years but to date no data are available for any African country except Egypt and Tanzania. In this study, we determined the prevalence of Blastocystis STs in populations from Libya, Liberia and Nigeria, as well as expanding the dataset available for the UK. A total of 356 Blastocystis STs were identified in this study, 271 from the UK, 38 from Libya, 25 from Liberia and 22 from Nigeria. SSU rRNA gene sequences revealed the presence of eight of the nine STs known from humans but at varying frequencies between countries. ST1 was the most common ST in Libya and Nigeria whereas ST3 showed the highest frequency in the other two countries, as indeed is the case in most populations around the world. ST4 was absent in Libya and ST2 in Nigeria, while no ST5, ST6, ST8 or ST9 infections were detected in any of the three African populations. The picture emerging from this and other surveys suggests that there is significant variation in ST prevalence between populations. Some of the possible reasons for and implications of this diversity are discussed. (C) 2012 Elsevier B.V. All rights reserved.