The effect of dopamine depletion from the caudate nucleus of the common marmoset (Callithrix jacchus) on tests of prefrontal cognitive function
The effect of dopamine depletion from the caudate nucleus of the common marmoset (Callithrix jacchus) on tests of prefrontal cognitive function
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DOI：
10.1037/0735-7044.114.1.3
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发表时间：
2000-02-01
影响因子：
1.9
通讯作者：
Roberts, AC
中科院分区：
文献类型：
--
作者：
Collins, P;Wilkinson, LS;Roberts, AC
本研究探讨了普通绒猴（Callithrix jacchus）尾状核多巴胺耗竭对前额叶损伤敏感任务（注意定势转移和空间延迟反应）的影响。有一个显着的损害在空间延迟反应任务的性能，但性能的注意力转移任务相对保存，除了在以前的相关知觉维度的重新参与减值。这种损伤模式与前额叶皮层兴奋性毒性损伤和帕金森病患者的损伤模式不同。虽然它是不可能的，以确定特定的认知功能，是独立的多巴胺能调制的尾状核，由于部分性质的病变，结果确实提供了洞察那些认知过程，似乎最依赖于尾状核多巴胺。
This study examined the effects of depletion of dopamine from the caudate nucleus of the common marmoset (Callithrix jacchus), on tasks sensitive to prefrontal damage (attentional set-shifting and spatial delayed response). There was a marked impairment in performance on the spatial delayed response task, but performance on the attentional set-shifting task was relatively preserved except for an impairment in re-engagement of a previously relevant perceptual dimension. This pattern of impairment is distinct from that seen after excitotoxic lesions of the prefrontal cortex and in patients with Parkinson's disease. Though it is not possible to identify specific cognitive functions that are independent of dopaminergic modulation of the caudate nucleus, due to the partial nature of the lesion, the results do provide insight into those cognitive processes that appear most dependent on caudate dopamine.