GADOLINIUM-DOTA ENHANCED MR IMAGING OF INTRACRANIAL LESIONS
GADOLINIUM-DOTA ENHANCED MR IMAGING OF INTRACRANIAL LESIONS
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DOI：
10.1097/00004728-198905000-00002
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发表时间：
1989-05-01
影响因子：
1.3
通讯作者：
DESCHEPPER, AM
中科院分区：
文献类型：
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作者：
PARIZEL, PM;DEGRYSE, HR;DESCHEPPER, AM
钆1，4，7，10-四氮杂环十二烷-N，N“，N "”，N"-四乙酸（Gd-DOTA）是第一种用于临床的新型大环顺磁共振（MR）造影剂（钆穴状化合物）。钆-DOTA具有类似于钆二亚乙基三胺五乙酸（Gd-DTPA）的弛豫性质。我们报告了我们的初步临床经验，在38例颅内病变的MR研究前和注射Gd-DOTA后。疾病包括原发性和转移性脑肿瘤、脑梗死、血管畸形、脑膜瘤、血管外皮细胞瘤、神经鞘瘤和垂体大腺瘤。钆-DOTA以0.1mmol/kg体重的剂量静脉内施用。所有研究均在0.5 T系统上进行。与平扫T1和T2加权像（WI）相比，Gd-DOTA增强T1 WI有助于确定恶性轴内肿瘤（高级别胶质瘤、转移瘤）的解剖结构，并有助于鉴别肿瘤与水肿。低级别胶质瘤没有增强，在这些情况下，增强前T2加权序列被认为是更多的信息。在术后患者中，Gd-DOTA使我们能够证明残留肿瘤或肿瘤复发。轴外肿瘤（脑膜瘤、血管外皮细胞瘤、神经瘤）明显增强，可能反映了肿瘤的血管分布。根据我们的经验，使用Gd-DOTA改善了脑病变的解剖学定义，在某些情况下增加了MR的敏感性和特异性。我们发现Gd-DOTA是一种耐受性良好且有效的顺磁性造影剂。Gdolinium-DOTA可作为Gd-DTPA的替代水溶性MR造影剂。
Gadolinium 1,4,7,10-tetraazacyclododecane-N,N'',N'''',N''''''-tetraacetic acid (Gd-DOTA) is the first of a new class of macrocyclic paramagnetic magnetic resonance (MR) contrast agents (gadolinium cryptelates) to be used in clinical practice. Gadolinium-DOTA possesses relaxation properties similar to those of gadolinium diethylene triamine pentaacetic acid (Gd-DTPA). We report our initial clinical experience in 38 patients with intracranial lesions studied with MR before and after injection of Gd-DOTA. Diseases included primary and metastatic brain tumor, cerebral infarct, vascular malformation, meningioma, hemangiopericytoma, schwannoma, and pituitary macroadenoma. Gadolinium-DOTA was administered intravenously in a dosage of 0.1 mmol/kg body weight. All studies were performed on a superconductive 0.5 T system. As compared to noncontrast T1- and T2-weighted images (WI), Gd-DOTA enhanced T1 WI were useful in defining the anatomy of malignant intraaxial tumors (high-grade glioma, metastasis) and in tumor versus edema differentiation. Low-grade gliomas did not enhance; in these cases the precontrast T2-weighted sequence was found to be more informative. In postoperative patients, Gd-DOTA allowed us to demonstrate residual tumor or tumor recurrence. Extraaxial tumors (meningioma, hemangiopericytoma, neuroma) enhanced markedly, presumably reflecting tumor vascularity. In our experience, the use of Gd-DOTA improves the anatomic definition of cerebral lesions and in some cases increases both MR sensitivity and specificity. We found Gd-DOTA to be a well tolerated and effective paramagnetic contrast agent. Gadolinium-DOTA can be considered as an alternative water-soluble MR contrast agent to Gd-DTPA.