The relationship between resting electroencephalogram oscillatory abnormalities and schizotypal personality traits in the first-degree relatives of schizophrenia patients
The relationship between resting electroencephalogram oscillatory abnormalities and schizotypal personality traits in the first-degree relatives of schizophrenia patients
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DOI：
10.1097/wnr.0000000000001350
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发表时间：
2019-12-10
期刊：
影响因子：
1.7
通讯作者：
Liu, Xufeng
中科院分区：
文献类型：
--
作者：
Chen, Chen;Huang, Wei;Liu, Xufeng
虽然大量研究表明精神分裂症及其一级亲属和典型人格者存在静息态脑电振荡异常，但结果并不一致，没有研究发现一级亲属的脑电图（EEG）异常与典型人格之间存在关系。本研究旨在验证精神分裂症患者及其一级亲属睁眼静息状态下脑电功率谱的变化，并探讨脑电功率谱与精神分裂症患者一级亲属典型人格特征的关系。本研究的参与者样本包括33名健康的正常对照，35名精神分裂症患者的未受影响的一级亲属和35名精神分裂症患者。通过重复测量方差分析考察了静息脑电频带功率的组间差异，并通过Pearson相关分析考察了脑电功率与典型人格特质之间的相关性。结果表明，精神分裂症患者在睁眼静息状态下，大脑前区和中央区的δ、θ和α活动均较正常对照组明显增强。在精神分裂症患者一级亲属中首次发现γ波功率与典型人格特质呈负相关。总之，这些结果表明，低频脑电图活动可能是精神分裂症的脑病理生理变化的神经表现，和γ带活动可能是一种方法来衡量的遗传易感性的障碍。版权所有（C）2019威科医疗集团All rights reserved.
Although a large amount of studies have manifested resting state electroencephalogram oscillatory abnormalities in schizophrenia and their first-degree relatives and in schizotype, the results are far from consistent and no research found any relationship between electroencephalograph (EEG) abnormalities and schizotypal personality in first-degree relatives. The present study is to verify the modifications of EEG power spectra in eyes-open resting state of schizophrenia and first-degree relatives, and to investigate associations between EEG band power and schizotypal personality traits in first-degree relatives of schizophrenia patients. Participant samples in this study consisted of 33 healthy normal controls, 35 unaffected first-degree relatives of schizophrenia patients and 35 schizophrenia patients. Group differences in resting EEG band power were examined via repeated-measures analysis of variance, and correlation between EEG power and schizotypal personality traits via Pearson Correlation analysis. The results showed that patients with schizophrenia exhibited increased delta, theta and alpha activity over anterior and central regions in eyes-open resting state compared with that of normal control. Gamma band power was found for the first time to be negatively correlated to schizotypal personality traits in first-degree relatives of schizophrenia patients. To conclusion, these findings suggested that low-frequency EEG activity might be neural manifestations of pathophysiological changes in the brain of schizophrenia, and gamma band activity might be an approach to measure the genetic liability of the disorder. Copyright (C) 2019 Wolters Kluwer Health, Inc. All rights reserved.