In Vitro Co-Culture Models of Breast Cancer Metastatic Progression towards Bone.
In Vitro Co-Culture Models of Breast Cancer Metastatic Progression towards Bone.
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DOI：
10.3390/ijms17091405
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发表时间：
2016-08-25
影响因子：
5.6
通讯作者：
Moretti M
中科院分区：
文献类型：
--
作者：
Arrigoni C;Bersini S;Gilardi M;Moretti M
晚期乳腺癌的骨转移通常需要经过多个步骤，包括细胞从原发肿瘤脱离，进入血流，粘附到内皮细胞，外渗到骨中，最终形成恶性循环，导致广泛的骨溶解。近年来，肿瘤细胞与继发器官微环境之间的串扰越来越受到人们的关注，被认为是所有转移过程中的一个重要方面。为了研究肿瘤与微环境之间复杂的相互关系，已经建立了体外和体内模型。体外模型比体内模型有一些优势，主要是可以在受控条件下彻底解剖，并且只使用人类细胞来研究转移进展背后的细胞和分子机制。在本文中，我们将回顾体外共培养模型的主要结果，描述在乳腺癌和骨细胞之间的串扰中激活的驱动不同转移步骤的机制。
Advanced breast cancer frequently metastasizes to bone through a multistep process involving the detachment of cells from the primary tumor, their intravasation into the bloodstream, adhesion to the endothelium and extravasation into the bone, culminating with the establishment of a vicious cycle causing extensive bone lysis. In recent years, the crosstalk between tumor cells and secondary organs microenvironment is gaining much attention, being indicated as a crucial aspect in all metastatic steps. To investigate the complex interrelation between the tumor and the microenvironment, both in vitro and in vivo models have been exploited. In vitro models have some advantages over in vivo, mainly the possibility to thoroughly dissect in controlled conditions and with only human cells the cellular and molecular mechanisms underlying the metastatic progression. In this article we will review the main results deriving from in vitro co-culture models, describing mechanisms activated in the crosstalk between breast cancer and bone cells which drive the different metastatic steps.
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影响因子：
3.8
作者：
Hess, KR;Pusztai, L;Hortobagyi, GN
通讯作者：
Hortobagyi, GN
影响因子：
4.8
作者：
Chen, Yan;Shi, Heidi Y.;Zhang, Ming
通讯作者：
Zhang, Ming
影响因子：
21.3
作者：
通讯作者：
--
DOI：
10.1186/bcr2781
发表时间：
2010
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Chen YC;Sosnoski DM;Mastro AM
通讯作者：
Mastro AM
影响因子：
4
作者：
Holen, I.;Nutter, F.;Ottewell, Penelope D.
通讯作者：
Ottewell, Penelope D.