Hyperbaric oxygen therapy for nonarteritic anterior ischemic optic neuropathy
Hyperbaric oxygen therapy for nonarteritic anterior ischemic optic neuropathy
复制标题
DOI：
10.1016/s0002-9394(14)72114-2
复制
发表时间：
1996-10-01
影响因子：
4.2
通讯作者：
Alexander, JM
中科院分区：
文献类型：
--
作者：
Arnold, AC;Hepler, RS;Alexander, JM
目的：评价高压氧治疗急性非动脉炎性前部缺血性视神经病变的疗效。方法：对20例(22只眼)急性非动脉性前部缺血性视神经病变患者进行高压氧治疗，每日2次，每次90分钟，每次90分钟，共10天。比较27例未经治疗的急性非动脉炎性前部缺血性视神经病变患者的平均视力和平均敏感度丧失的变化，以及视力改变或平均敏感度丧失的患者与对照组的比例。结果：两组患者在末次检查时视力均值均有增加，而对照组视力增加幅度较大，但差异无统计学意义。平均视野敏感度损失轻微增加；尽管对照组增加较小，但组间差异不显著。在视力评分或平均敏感度丧失的患者比例上，两组之间没有显著差异。按治疗时间延迟分层并不表明9d内的治疗效果优于对照组或治疗后的患者。结论：100%氧气和2.0绝对压的高压氧治疗对急性非动脉炎性前部缺血性视神经病变患者的视力或视野没有明显改善。
PURPOSE: To evaluate the effectiveness of hyperbaric oxygen therapy in reducing optic nerve damage in acute nonarteritic anterior ischemic optic neuropathy.METHODS: Twenty-two eyes in 20 patients with acute nonarteritic anterior ischemic optic neuropathy were treated with hyperbaric oxygen (100% oxygen, 2.0 absolute atmospheres of pressure) in two 90-minute inhalation sessions per day for ten days. Changes in mean visual acuity and mean sensitivity loss were compared with those of 27 untreated control patients with acute nonarteritic anterior ischemic optic neuropathy, and proportions of patients with a change in acuity or mean sensitivity loss were compared with controls. Similar analysis was performed on subgroups based on time delay from symptom onset to therapy.RESULTS: Mean values for visual acuity were increased at final examination in both groups; although the increase was greater in controls, the difference was not statistically significant. Mean visual field sensitivity loss was minimally increased; although the increase was smaller incontrols, the difference between groups was not significant. There was no significant difference between groups in proportions of patients with change in acuity score or mean sensitivity loss. Stratification by time delay to therapy did not suggest that treatment within nine days produced better visual results than that for either controls or those treated later.CONCLUSIONS: Hyperbaric oxygen therapy using 100% oxygen and 2.0 absolute atmospheres of pressure did not produce a significant improve ment in visual acuity or visual field for patients with acute nonarteritic anterior ischemic optic neuropathy.