Modulation of reward in a live social context as revealed through interactive social neuroscience.
Modulation of reward in a live social context as revealed through interactive social neuroscience.
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DOI：
10.1080/17470919.2017.1339635
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发表时间：
2018-08
影响因子：
2
通讯作者：
McPartland JC
中科院分区：
文献类型：
--
作者：
Rolison MJ;Naples AJ;Rutherford HJV;McPartland JC
对自闭症谱系障碍(ASD)的社会神经科学研究得出了不一致的结果，尽管ASD的特点是通过行为观察难以进行社交和沟通。特别是，自闭症患者的特定病因以及大脑的功能和结构分析尚未得到一致的确认。到目前为止，大多数社会神经科学研究都集中在一个人观看静态图像上。利用以双脑记录为特征的互动社会神经科学的研究为神经发育障碍的研究提供了巨大的希望。奖赏处理与ASD的病理有关，然而，混合的研究结果带来了关于奖赏处理缺陷在ASD中可能扮演的角色的不确定性。目前的研究使用双脑脑电记录来检查现场互动过程中的奖励处理及其与自闭症特征的关系。16名典型发育(TD)的成年人与计算机和人类伙伴玩了一场竞争性的寻宝游戏。脑电结果显示，在与人类竞争对手的现场互动中，神经对奖励结果的敏感度增强。此外，自闭症特征水平较高的个体在现场互动中对奖励结果的敏感度降低。这些发现为与自闭症特征相关的奖励处理机制提供了新的见解，并支持了互动社会神经科学技术在研究发育障碍方面的必要效用。
Social neuroscience research investigating autism spectrum disorder (ASD) has yielded inconsistent findings, despite ASD being well-characterized by difficulties in social interaction and communication through behavioral observation. In particular, specific etiologies and functional and structural assays of the brain in autism have not been consistently identified. To date, most social neuroscience research has focused on a single person viewing static images. Research utilizing interactive social neuroscience featuring dual-brain recording offers great promise for the study of neurodevelopmental disabilities. Reward processing has been implicated in the pathology of ASD, yet mixed findings have brought uncertainty about the role reward processing deficits may play in ASD. The current study employed dual-brain EEG recording to examine reward processing during live interaction and its relation to autistic traits. 16 typically-developing (TD) adults played a competitive treasure-hunt game against a computer and against a human partner. EEG results revealed enhanced neural sensitivity to reward outcome during live interaction with a human competitor. Further, individuals with higher levels of autistic traits demonstrated reduced sensitivity to reward outcome during live interaction. These findings provide novel insight into reward processing mechanisms associated with autistic traits, as well as support the necessary utility of interactive social neuroscience techniques to study developmental disorders.