Epigenetic targets of arsenic: emphasis on epigenetic modifications during carcinogenesis.
Epigenetic targets of arsenic: emphasis on epigenetic modifications during carcinogenesis.
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DOI：
10.1615/jenvironpatholtoxicoloncol.2014012066
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
R. Roy;Young-Ok Son;P. Pratheeshkumar;Lei Wang;J. A. Hitron;Sasidharan Padmaja Divya;Rakesh D;Donghern Kim;Yuan-qin Yin;Zhuo Zhang;Xianglin Shi
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文献类型：
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作者：
R. Roy;Young-Ok Son;P. Pratheeshkumar;Lei Wang;J. A. Hitron;Sasidharan Padmaja Divya;Rakesh D;Donghern Kim;Yuan-qin Yin;Zhuo Zhang;Xianglin Shi
DNA甲基化和组蛋白修饰促进染色质结构的开放和关闭，从而在不改变DNA序列的情况下影响基因表达。表观遗传标记在不同水平上调节染色质结构的动态性质：DNA、组蛋白、非编码RNA以及更高阶的染色质结构。越来越多的证据有力地表明，砷致癌涉及表观遗传标志物的频繁变化。然而，利用全基因组方法在鉴定砷引起的表观遗传变化方面已经取得了进展；这些表观遗传变化的生物学意义尚不清楚。此外，砷诱导染色质状态的改变通过表观遗传机制改变基因表达。本文就砷在致癌过程中引起的表观遗传学改变的最新文献进行了综述。我们强调需要跨代研究，以阐明砷的生物学意义和广泛的毒性。
DNA methylation and histone modification promote opening and closure of chromatin structure, which affects gene expression without altering the DNA sequence. Epigenetic markers regulate the dynamic nature of chromatin structure at different levels: DNA, histone, noncoding RNAs, as well as the higher-order chromatin structure. Accumulating evidence strongly suggests that arsenic-induced carcinogenesis involves frequent changes in the epigenetic marker. However, progress in identifying arsenic-induced epigenetic changes has already been made using genome-wide approaches; the biological significance of these epigenetic changes remains unknown. Moreover, arsenic-induced changes in the chromatin state alter gene expression through the epigenetic mechanism. The current review provides a summary of recent literature regarding epigenetic changes caused by arsenic in carcinogenesis. We highlight the transgenerational studies needed to explicate the biological significance and toxicity of arsenic over a broad spectrum.