The global burden of chronic obstructive pulmonary disease, number 3, The natural history of chronic obstructive pulmonary disease
The global burden of chronic obstructive pulmonary disease, number 3, The natural history of chronic obstructive pulmonary disease
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DOI：
10.1183/09031936.06.00024605
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发表时间：
2006-03-01
影响因子：
24.3
通讯作者：
Vestbo, J
中科院分区：
文献类型：
--
作者：
Mannino, DM;Watt, G;Vestbo, J
慢性阻塞性肺疾病（COPD）是美国发病率和死亡率的主要原因，并且仍然是少数持续增加的疾病之一。慢性阻塞性肺病的发生和进展在个体之间可能存在巨大差异。肺功能水平低仍然是 COPD 诊断的基石，也是预后的关键预测因素。然而，肺功能并不是决定 COPD 相关发病率和死亡率的唯一因素，体重指数、运动能力和合并症等因素是不良结果的重要预测因素。 COPD 的恶化是 COPD 患者生活质量和结果的额外重要指标。恶化的定义可能有所不同，从症状加重到与慢性阻塞性肺病相关的住院和死亡。 COPD 加重在肺功能水平较低的患者中更为常见，并可能导致肺功能更快下降。更好地了解慢性阻塞性肺病的自然史可能会更好地定义特定的慢性阻塞性肺病表型、更好的干预措施和改善的结果。
Chronic obstructive Pulmonary disease (COPD) is a leading cause of morbidity and mortality in the USA, and it remains one of the few diseases that continues to increase its numbers. The development and progression of COPD can vary dramatically between individuals. A low level of lung function remains the cornerstone of COPD diagnosis and is a key predictor of prognosis. Lung function, however, is not the only factor in determining morbidity and mortality related to COPD, with factors such as body mass index, exercise capability and comorbid disease being important predictors of poor outcomes. Exacerbations of COPD are additional important indicators of both quality of life and Outcomes in COPD patients. Definitions of exacerbations can vary, ranging from an increase in symptoms to COPD-related hospitalisations and death. COPD exacerbations are more common in patients with lower levels Of lung function and may lead to more rapid declines in lung function. Better Understanding of the natural history of COPD may lead to better definitions of specific COPD phenotypes, better interventions and improved outcomes.