Intrasubject reproducibility of presurgical language lateralization and mapping using fMRI
Intrasubject reproducibility of presurgical language lateralization and mapping using fMRI
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DOI：
10.1212/01.wnl.0000049934.34209.2e
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发表时间：
2003-03-25
期刊：
影响因子：
9.9
通讯作者：
Elger, CE
中科院分区：
文献类型：
--
作者：
Fernández, G;Specht, K;Elger, CE
背景：功能磁共振成像正在成为一种标准的工具，用于手术前侧化和绘制涉及语言处理的大脑区域。然而，其在主体内的可重复性尚未得到充分的探索。目的：评价连续接受癫痫手术评估的患者语言功能磁共振成像的内测信度和重测信度。方法：对34例未入选患者进行一次调查（试验内信度），对12例进行两次调查（重测信度）。成像系列包括一个交替的25秒同义词判断条件和一个重复15次的25秒字母匹配条件。通过比较一个全局和三个区域侧化指数（布洛卡区、剩余前额叶皮层、颞顶叶区）和逐体素的基础（类内相关系数、重叠百分比、t值相关性），评估第1阶段前半部分和第1阶段和第2阶段激活图的可重复性。结果：在会话内和会话间实现了高可靠性的全球和区域语言侧化。再现性均匀分布在两个半球，但不是在每个半球内。额叶激活比颞顶叶激活更可靠。根据所选择的统计阈值，逐体素分析显示，从第一次和第二次调查中获得的激活的平均重叠高达48.9%。结论：语言功能磁共振成像（fMRI）在确定个体非选择性癫痫患者语言表征的整体和区域偏侧方面是足够可靠的。
Background: fMRI is becoming a standard tool for the presurgical lateralization and mapping of brain areas involved in language processing. However, its within-subject reproducibility has yet to be fully explored. Objective: To evaluate within-test and test-retest reliability of language fMRI in consecutive patients undergoing evaluation for epilepsy surgery. Methods: Thirty-four unselected patients were investigated once (within-test reliability) and 12 patients twice (test-retest reliability). The imaging series consisted of an alternating 25-second synonym judgment condition with a 25-second letter-matching condition repeated 15 times. Reproducibility of activation maps of the first and second half of session 1 or activation maps of sessions 1 and 2 was evaluated by comparing one global and three regional lateralization indexes (Broca's area, remaining prefrontal cortex, temporoparietal area) and on a voxel-by-voxel basis (intraclass correlation coefficient, percentage overlap, correlation of t-values). Results: Global and regional language lateralization was achieved with high reliability within and across sessions. Reproducibility was evenly distributed across both hemispheres but not within each hemisphere. Frontal activations were more reliable than temporoparietal ones. Depending on the statistical threshold chosen, the voxel-by-voxel analysis revealed a mean overlap of activations derived from the first and second investigation of up to 48.9%. Conclusion: Language fMRI proved sufficiently reliable for the determination of global and regional lateralization of language representation in individual unselected patients with epilepsy.