Chronic consumption of a high-fat diet during pregnancy causes perturbations in the serotonergic system and increased anxiety-like behavior in nonhuman primate offspring.
Chronic consumption of a high-fat diet during pregnancy causes perturbations in the serotonergic system and increased anxiety-like behavior in nonhuman primate offspring.
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DOI：
10.1523/jneurosci.5560-09.2010
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发表时间：
2010-03-10
期刊：
影响因子：
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通讯作者：
Grove KL
中科院分区：
文献类型：
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作者：
Sullivan EL;Grayson B;Takahashi D;Robertson N;Maier A;Bethea CL;Smith MS;Coleman K;Grove KL
儿童肥胖与行为/心理障碍的风险增加有关，包括抑郁、焦虑、学习不良和注意力缺陷障碍。由于大多数育龄妇女超重或肥胖，饮食中脂肪含量高，因此研究母亲营养过剩对调节后代行为的大脑回路发育的影响至关重要。使用非人灵长类动物（NHP）模型的饮食诱导的肥胖，我们发现，母亲高脂肪饮食（HFD）消费引起的扰动，在中央多巴胺能系统的胎儿后代。此外，HFD喂养的母亲的女婴表现出增加的焦虑，以应对威胁性的新物体。这些发现具有重要的临床意义，因为它们表明，在妊娠期间暴露于母体HFD消费，独立于肥胖，增加了发生行为障碍如焦虑的风险。
Childhood obesity is associated with increased risk of behavioral/psychological disorders including depression, anxiety, poor learning, and attention deficient disorder. As the majority of women of child-bearing age are overweight or obese and consume a diet high in dietary fat, it is critical to examine the consequences of maternal overnutrition on the development of brain circuitry that regulates offspring behavior. Using a nonhuman primate (NHP) model of diet-induced obesity, we found that maternal high-fat diet (HFD) consumption caused perturbations in the central serotonergic system of fetal offspring. In addition, female infants from HFD fed mothers exhibited increased anxiety in response to threatening novel objects. These findings have important clinical implications as they demonstrate that exposure to maternal HFD consumption during gestation, independent of obesity, increases the risk of developing behavioral disorders such as anxiety.