Suppression of human cortico-motoneuronal excitability during the Stop-signal task
Suppression of human cortico-motoneuronal excitability during the Stop-signal task
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DOI：
10.1016/j.clinph.2009.06.027
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发表时间：
2009-09-01
影响因子：
4.7
通讯作者：
Fukuyama, Hidenao
中科院分区：
文献类型：
--
作者：
Badry, Reda;Mima, Tatsuya;Fukuyama, Hidenao
目的：为了研究运动抑制是否是一种活跃的过程，并阐明其躯体组织结构，我们在停止信号任务中使用经颅磁刺激(TMS)研究了皮质运动神经元的兴奋性。方法：在25%的实验中，受试者被要求在GO信号后按下按钮；在GO信号之后有一定的时间延迟，指示受试者不要按下按钮。TMS以不同的时间延迟注射到左手或右手或腿部的主要运动区。结果：在GO提示后400ms给药时，成功停止试验时双侧手部和腿部肌肉的运动诱发电位(MEP)受到明显抑制，而失败停止试验时则无明显抑制。结论：停止信号任务中运动的自愿停止是一个主动的过程，它不仅可能抑制执行任务手的皮质运动神经元兴奋性，而且可能导致运动系统的广泛抑制。意义：对反应抑制的正常生理学的研究将有助于理解与运动抑制缺陷相关的神经精神障碍的病理生理学。(C)2009年国际临床神经生理学联合会。爱思唯尔爱尔兰有限公司出版。版权所有。
Objective: To investigate whether motor suppression is an active process, and to clarify its somatotopic organization, we investigated cortico-motoneuronal excitability using transcranial magnetic stimulation (TMS) during the Stop-signal task.Methods: Subjects were asked to press a button following a Go cue; a Stop-signal followed the Go cue by a certain time delay in 25% of trials, indicating to subjects that they were not to press the button. TMS was given to the primary motor area of the left or right-hand or leg at variable time delays. Motor evoked potentials (MEPs) were recorded from the hand and leg muscles bilaterally.Results: When TMS was delivered 400 ms after the Go cue, there was significant suppression of the MEPs of the bilateral hand and leg muscles during successful Stop trials, but not during failed Stop trials. Conclusions: The voluntary stopping of movement in the Stop-signal task is an active process, which likely suppresses not only the cortico-motoneuronal excitability of the task-performing hand, but also causes the widespread suppression of the motor system.Significance: Studies in the normal physiology of response inhibition would be of help in understanding the pathophysiology of neuro-psychiatric disorders associated with deficits in motor suppression. (C) 2009 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.