Possible effects of polychlorinated biphenyls and organochlorinated pesticides on the thyroid after long-term exposure to heavy environmental pollution
Possible effects of polychlorinated biphenyls and organochlorinated pesticides on the thyroid after long-term exposure to heavy environmental pollution
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DOI：
10.1097/01.jom.0000058346.05741.b0
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发表时间：
2003-05-01
影响因子：
3.2
通讯作者：
Klimes, I
中科院分区：
文献类型：
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作者：
Langer, P;Kocan, A;Klimes, I
这项工作的目的是研究高环境暴露于多氯联苯（PCBs）和其他有机氯对甲状腺的影响。甲状腺体积，低回声和结节（超声），抗甲状腺过氧化物酶（抗TPO）抗体的存在下，和异常的促甲状腺激素（TSH）的血清水平（放射免疫法）进行了检查，在101名成年人从PCB污染的地区在360个对照。用高分辨气相色谱法测定了血清中PCBs、六氯苯、γ-六氯环己烷（HCH）、p，p '-DDT（1，1，1-三氯-2，2'-双（对氯苯基）乙烷）和p，p '-DDE（1，1-二氯-2，2'-双（对氯苯基）乙烯）的水平。与对照区（2045 +/- 147纳克/克）相比，污染区的多氯联苯含量非常高（7300 +/- 871纳克/克脂质）。除六氯环己烷（HCH）外，其他有机氯与其总量呈正相关（P < 0.001）。在污染区，甲状腺体积最高（18.7 +/- 2.32毫升;平均值+/-标准误）集中在23名受试者（17名男性和6名女性）中，PCB水平高于10，000纳克/克（范围10，000 - 58，667纳克/克）。其余438例受试者的甲状腺体积为14.2 +/- 0.29 mL。这些数据表明，可能有一个阈值血清PCB水平约10，000 nglg，可能会影响甲状腺体积。两因素方差分析表明，污染区甲状腺体积均显著高于对照区（P < 0.001）。污染区男性甲状腺低回声、甲状腺结节、抗-TPO阳性和TSH水平异常的发生率均高于对照区男性，而女性则无此差异。甲状腺体积增加和潜在甲状腺功能障碍的指标与长期环境暴露于多氯联苯有关。这些对甲状腺的影响仅限于PCB水平超过10，000 ngl g脂质（甲状腺体积）的受试者和来自污染地区的男性（甲状腺低回声、甲状腺结节、抗TPO阳性和TSH异常）。
The purpose of this work was to study the effects of high environmental exposure to polychlorinated biphenyls (PCBs) and other organochlorines on the thyroid. Thyroid volume, hypoechogenicity and nodules (by ultrasound), presence of antithyroid peroxidase (anti-TPO) antibodies, and abnormal thyroid-stimulating hormone (TSH) levels in serum (by radioimmunoassay) were examined in 101 adults from the PCB-polluted area in 360 controls. Serum levels of PCBs, hexachlorobenzene, gamma-hexachlorotyclohexane (HCH), p,p'-DDT(1, 1, 1-trichluro-2,2' bis(p-chlorophenyl)ethane), and p,p'-DDE(1,1-dichloro-2,2'-bis(p-chlorophenyl)ethene) were measured by high-resolution gas chromatography. Very high Levels of PCBs were found in the polluted area (7300 +/- 871 ng/g lipids) compared with controls (2045 +/- 147 ng/g). Positive correlations (P < 0.001) were found between the levels of all organochlorines and their total except for hexachlarocyclohexane (HCH). In the polluted area, the highest thyroid volumes (18.7 +/- 2.32 mL; mean +/- SE) were clustered among 23 subjects (17 males and six females) with PCB levels above 10, 000 ng/g (range 10,000-58,667 ng/g). In the remaining 438 subjects the thyroid volume was 14.2 +/- 0.29 mL. These data suggest that there might be a threshold serum PCB level of approximately 10,000 nglg that may influence the thyroid volume. A two-way ANOVA showed that all thyroid-volumes in the polluted area were significantly higher (P < 0.001) than in the control area. In males from the polluted area, the frequencies of thyroid hypoechogenicity, thyroid nodules, positive anti-TPO, and abnormal TSH level were higher than in males from the control area, whereas such differences were not observed in females. Increased thyroid volume and indicators of potential thyroid dysfunction were associated with long-term environmental exposure to PCBs. These effects on the thyroid were confined to subjects with PCB levels above 10, 000 nglg of lipid (thyroid volume) and to males from the polluted area (thyroid hypoechogenicity, thyroid nodules, positive anti-TPO, and abnormal TSH).