Significance of E2F-1 overexpression in epithelial ovarian cancer
Significance of E2F-1 overexpression in epithelial ovarian cancer
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DOI：
10.1111/j.1525-1438.2007.01044.x
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发表时间：
2008-05-01
影响因子：
4.8
通讯作者：
Kim, J. Y.
中科院分区：
文献类型：
--
作者：
Suh, D. S.;Yoov, M. S.;Kim, J. Y.
E2 F-1是Rb通路的下游调节因子，是在控制细胞周期进程中起关键作用的转录因子。E2 F-1表达和Rb通路的失调参与了肿瘤的发生。本研究的目的是评估E2 F-1表达和Rb通路的改变，并阐明其与卵巢上皮性癌（EOC）的临床和病理参数的相关性。我们采用免疫组化和组织芯片方法研究了72例EOC患者E2 F-1的门控过表达和p16（INK 4a）、cyclin D1、CDK 4和pRb的改变。45.8%的样本中检测到E2 F-1过表达。p16（INK 4a）、cyclin D1、CDK 4和pRb的异常表达率分别为33.3%、11.1%、12.5%和38.9%。E2 F-1过表达与Rb通路的改变无关。E2 F-1过表达与FIGO分期、组织学分级和有丝分裂指数相关;在多变量分析中，E2 F-1过表达与FIGO分期沿着是一个有价值的预后变量。结果表明，E2 F-1在EOC中具有促生长作用，E2 F-1过表达可能为EOC提供有用的预后指标。
E2F-1 is a downstream regulator of the Rb pathway and is a transcription factor that plays a key role in the control of cell cycle progression. Deregulation of E2F-1 expression and Rb pathway is involved in carcinogenesis. The aim of this study was to evaluate E2F-1 expression and Rb pathway alteration and to elucidate their correlation with clinical and pathologic parameters in epithelial ovarian cancer (EOC). We investigated gated overexpression of E2F-1 and alterations of p16(INK4a), cyclin D1, CDK4, and pRb using immunohisto chemistry and tissue microarray methods in 72 EOC patients. Overexpression of E2F-1 was detected in 45.8% of samples. The overall abnormal expression frequencies of p16(INK4a), cyclin D1, CDK4, and pRb were 33.3%, 11.1%, 12.5%, and 38.9%, respectively. E2F-1 overexpression was not associated with alteration of the Rb pathway. E2F-1 overexpression was correlated with FIGO stage, histologic grade, and mitotic index; it was a valuable prognostic variable along with FIGO stage in the multivariated analysis. The results suggest that E2F-1 has a growth-promoting effect in EOC and that E2F-1 overexpression may provide a useful prognostic indicator for EOC.