Genetic dissection of mouse distal chromosome 1 reveals three linked BMD QTLs with sex-dependent regulation of bone phenotypes
Genetic dissection of mouse distal chromosome 1 reveals three linked BMD QTLs with sex-dependent regulation of bone phenotypes
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DOI：
10.1359/jbmr.070419
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发表时间：
2007-08-01
影响因子：
6.2
通讯作者：
Rosen, Clifford J.
中科院分区：
文献类型：
--
作者：
Beamer, Wesley G.;Shultz, Kathryn L.;Rosen, Clifford J.
遗传分析与小鼠同源株远端Chr 1已经确定了三个密切相关的QTL调节股骨vBMD，中间骨干皮质厚度，和骨小梁显微结构的性别依赖性的方式。远端小鼠Chr 1和人类1 q21 -24之间的同源关系提供了寻找皮质骨和松质骨共同调控基因的可能性。
Genetic analyses with mouse congenic strains for distal Chr1 have identified three closely linked QTLs regulating femoral vBMD, mid-diaphyseal cortical thickness, and trabecular microstructure in a sex-dependent fashion. The homologous relationship between distal mouse Chr 1 and human 1q21-24 offers the possibility of finding common regulatory genes for cortical and trabecular bone.