Prevalence and prognosis of synchronous Colorectal cancer: A Dutch population-based study
Prevalence and prognosis of synchronous Colorectal cancer: A Dutch population-based study
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DOI：
10.1016/j.canep.2010.12.007
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发表时间：
2011-10-01
影响因子：
2.6
通讯作者：
van Leerdam, Monique E.
中科院分区：
文献类型：
--
作者：
Mulder, Sanna A.;Kranse, Ries;van Leerdam, Monique E.
背景：相当比例的结直肠癌（CRC）患者被诊断为同步性CRC。然而，关于同步性结直肠癌的发病率、危险因素和预后的大规模人群研究很少，需要更好地确定诊断为结肠肿瘤的患者中同步性结直肠癌的风险。研究方法：1995年至2006年期间所有新诊断的CRC均来自荷兰鹿特丹癌症登记处，并对同步CRC进行研究。结果：在13,683例确诊为CRC的患者中，534例（3.9%）被诊断为同步性CRC。男性（OR 1.54，95%CI 1.29-1.84）和年龄>70岁的患者（OR 1.83，95%CI 1.39-2.40）发生同步性结直肠癌的风险显著较高。同步结直肠癌患者发生远处转移的风险显著较高（OR 1.69，95%CI 1.27-2.26）。在34%（184/534）中，两个肿瘤位于不同的手术节段。在对远处转移进行多变量校正后，同步性结直肠癌患者的5年相对生存率与孤立性结直肠癌患者相似。结论：25例结直肠癌患者中有1例同时存在结直肠癌。在多变量分析中，当对首次出现的远处转移进行校正时，同步性CRC患者的生存率与孤立性CRC患者相似。三分之一的同期结直肠癌位于不同的手术节段，这强调了手术前最好进行全结肠检查的重要性。(C)2011爱思唯尔有限公司版权所有。
Background: A noticeable proportion of colorectal cancer (CRC) patients are diagnosed with synchronous CRC. Large population-based studies on the incidence, risk factors and prognosis of synchronous CRC are, however, scarce, and are needed for better determination of risks of synchronous CRC in patients diagnosed with colonic neoplasia. Methods: All newly diagnosed CRC between 1995 and 2006 were obtained from the Rotterdam Cancer Registry in The Netherlands, and studied for synchronous CRC. Results: Of the 13,683 patients diagnosed with CRC, 534 patients (3.9%) were diagnosed with synchronous CRC. The risk of having synchronous CRC was significantly higher in men (OR 1.54, 95% CI 1.29-1.84) and in patients aged >70 years (OR 1.83,95% CI 1.39-2.40). Synchronous CRC patients had a significantly higher risk of distant metastases (OR 1.69, 95% CI 1.27-2.26). In 34% (184/534) the two tumours were located in different surgical segments. Five-year relative survival of synchronous CRC was similar to patients with solitary CRC after multivariate adjustment for the presence of distant metastases. Conclusion: One out of 25 patients diagnosed with CRC presents with synchronous CRC. In the multivariate analysis, survival of patients with synchronous CRC was similar to patients with solitary CRC, when corrected for the presence of distant metastases at first presentation. One third of the synchronous CRC were located in different surgical segments, which stresses the importance of performing total colon examination preferably prior to surgery. (C) 2011 Elsevier Ltd. All rights reserved.