ONJ in Two Dental Practice-Based Research Network Regions
ONJ in Two Dental Practice-Based Research Network Regions
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DOI：
10.1177/0022034510387795
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发表时间：
2011-04-01
影响因子：
7.6
通讯作者：
Richman, J.
中科院分区：
文献类型：
--
作者：
Fellows, J. L.;Rindal, D. B.;Richman, J.
下颌骨坏死（ONJ）在人群中的发病率较低，但具体情况尚不清楚。潜在的危险因素包括双膦酸盐治疗、类固醇治疗、骨质疏松症和头颈部放疗。这项基于牙科实践的研究网络研究估计了ONJ的发病率和二膦酸盐暴露和其他危险因素的比值比，使用关键词搜索和手工图表审查1995-2006年期间在两个大型医疗保健组织登记的年龄≥ 35岁的成年人的电子记录。我们在572，606名队列成员中发现了16例ONJ病例;通过牙科计划资源确定了另外7例病例。在23例病例（0.63/100，000患者年）中，20例（87%）至少有一个风险因素，6例（26%）接受过口服双膦酸盐。口服双膦酸盐的患者比未暴露患者发生ONJ的可能性高15.5（CI，6.0-38.7）;然而，ONJ病例的稀少数量限制了明确的结论，并表明口服双膦酸盐的ONJ绝对风险较低。
The incidence of osteonecrosis of the jaw (ONJ) in the population is low, but specifics are unknown. Potential risk factors include bisphosphonate treatment, steroid treatment, osteoporosis, and head/neck radiation. This Dental Practice-Based Research Network study estimated ONJ incidence and odds ratios from bisphosphonate exposure and other risk factors using a key word search and manual chart reviews of electronic records for adults aged >= 35 yrs enrolled during 1995-2006 in two large health-care organizations. We found 16 ONJ cases among 572,606 cohort members; seven additional cases were identified through dental plan resources. Among 23 cases (0.63 per 100,000 patient years), 20 (87%) had at least one risk factor, and six (26%) had received oral bisphosphonates. Patients with oral bisphosphonates were 15.5 (CI, 6.0-38.7) more likely to have ONJ than non-exposed patients; however, the sparse number of ONJ cases limits firm conclusions and suggests that the absolute risks for ONJ from oral bisphosphonates is low.