Auditory encoding abnormalities in children with autism spectrum disorder suggest delayed development of auditory cortex.
Auditory encoding abnormalities in children with autism spectrum disorder suggest delayed development of auditory cortex.
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DOI：
10.1186/s13229-015-0065-5
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发表时间：
2015
期刊：
影响因子：
6.2
通讯作者：
Roberts TP
中科院分区：
文献类型：
--
作者：
Edgar JC;Fisk Iv CL;Berman JI;Chudnovskaya D;Liu S;Pandey J;Herrington JD;Port RG;Schultz RT;Roberts TP
自闭症谱系障碍（ASD）儿童的听觉异常包括延迟的上级颞回听觉反应，刺激前后的上级颞回（STG）听觉振荡异常，以及非典型的半球偏侧化。这些异常可能与异常的大脑成熟有关。为了更好地了解大脑活动的变化作为年龄的函数，本研究调查了年龄和STG听觉时域和时频神经活动之间的关联。虽然306通道脑磁图（MEG）的数据被记录，500-和1000-Hz的音调300毫秒的持续时间双耳。可评价的数据来自63名典型发育儿童（TDC）（6至14岁）和52名ASD儿童（6至14岁）。获得T1加权结构MRI，并使用解剖学上约束到每个参与者的左右STG的单偶极子创建源模型。使用该源模型，获得左右50 ms（M50）、100 ms（M100）和200 ms（M200）时域和时频测量（总功率（TP）和试验间相干性（ITC））。配对t检验显示ASD与TDC的右侧STG M100潜伏期延迟（右侧500 Hz显著，右侧1000 Hz略微显著）。在左侧和右侧STG中，时间-频率分析显示，在150 ms后，ASD与TDC中的两个音调的4- 16-Hz TP在刺激前到刺激后增加更大。在右侧STG中，在200 ms后，TDC与ASD中观察到两种音调的更大的刺激后4至16 Hz ITC。年龄效应的分析表明，M200组的差异是由于ASD的成熟延迟，左和右M200随着年龄的增长，TDC下降，但在ASD显着减少。其他证据表明，在ASD的听觉皮层成熟延迟包括非典型的半球功能不对称，包括一个右与左M100潜伏期优势TDC，但不是ASD，和一个更强的左比右M50响应TDC，但不是ASD。目前的研究结果表明，自闭症儿童的初级/次级听觉区的发育成熟异常。据推测，听觉网络活动的成熟的纵向调查将表明在ASD的听觉处理系统的每个组件的延迟发展。本文的在线版本（doi：10.1186/s13229-015-0065-5）包含补充材料，可供授权用户使用。
Findings of auditory abnormalities in children with autism spectrum disorder (ASD) include delayed superior temporal gyrus auditory responses, pre- and post-stimulus superior temporal gyrus (STG) auditory oscillatory abnormalities, and atypical hemispheric lateralization. These abnormalities are likely associated with abnormal brain maturation. To better understand changes in brain activity as a function of age, the present study investigated associations between age and STG auditory time-domain and time-frequency neural activity. While 306-channel magnetoencephalography (MEG) data were recorded, 500- and 1000-Hz tones of 300-ms duration were binaurally presented. Evaluable data were obtained from 63 typically developing children (TDC) (6 to 14 years old) and 52 children with ASD (6 to 14 years old). T1-weighted structural MRI was obtained, and a source model created using single dipoles anatomically constrained to each participant’s left and right STG. Using this source model, left and right 50-ms (M50), 100-ms (M100), and 200-ms (M200) time-domain and time-frequency measures (total power (TP) and inter-trial coherence (ITC)) were obtained. Paired t tests showed a right STG M100 latency delay in ASD versus TDC (significant for right 500 Hz and marginally significant for right 1000 Hz). In the left and right STG, time-frequency analyses showed a greater pre- to post-stimulus increase in 4- to 16-Hz TP for both tones in ASD versus TDC after 150 ms. In the right STG, greater post-stimulus 4- to 16-Hz ITC for both tones was observed in TDC versus ASD after 200 ms. Analyses of age effects suggested M200 group differences that were due to a maturational delay in ASD, with left and right M200 decreasing with age in TDC but significantly less so in ASD. Additional evidence indicating delayed maturation of auditory cortex in ASD included atypical hemispheric functional asymmetries, including a right versus left M100 latency advantage in TDC but not ASD, and a stronger left than right M50 response in TDC but not ASD. Present findings indicated maturational abnormalities in the development of primary/secondary auditory areas in children with ASD. It is hypothesized that a longitudinal investigation of the maturation of auditory network activity will indicate delayed development of each component of the auditory processing system in ASD. The online version of this article (doi:10.1186/s13229-015-0065-5) contains supplementary material, which is available to authorized users.