Translational systems biology: Introduction of an engineering approach to the pathophysiology of the burn patient
Translational systems biology: Introduction of an engineering approach to the pathophysiology of the burn patient
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DOI：
10.1097/bcr.0b013e31816677c8
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发表时间：
2008-03-01
影响因子：
1.4
通讯作者：
Vodovotz, Yoram
中科院分区：
文献类型：
--
作者：
An, Gary;Faeder, James;Vodovotz, Yoram
烧伤患者的病理生理学表现出炎症反应复杂性的全谱。在急性期，炎症可能通过毛细血管渗漏、吸入性损伤的传播和多器官衰竭的发展产生负面影响。试图调解这些过程仍然是烧伤护理研究的中心课题。相反，炎症是伤口愈合后期过程的必要序幕和组成部分。尽管大量的信息涉及炎症的细胞和分子过程，存在着一个显着的差距之间的知识机制的病理生理学和有效的临床治疗方案的发展。转化系统生物学（Translational systems biology，TSB）是将动态数学建模和某些工程原理应用于生物系统，将机制与现象结合起来，重要的是修改临床实践。本研究将回顾TSB在炎症和伤口愈合领域的现有应用，将其与烧伤社区感兴趣的特定领域联系起来，并提出一个将TSB与传统烧伤研究联系起来的综合框架。
The pathophysiology of the burn patient manifests the full spectrum of the complexity of the inflammatory response. In the acute phase, inflammation may have negative effects via capillary leak, the propagation of inhalation injury, and development of multiple organ failure. Attempts to mediate these processes remain a central subject of burn care research. Conversely, inflammation is a necessary prologue and component in the later stage processes of wound healing. Despite the volume of information concerning the cellular and molecular processes involved in inflammation, there exists a significant gap between the knowledge of mechanistic pathophysiology and the development of effective clinical therapeutic regimens. Translational systems biology (TSB) is the application of dynamic mathematical modeling and certain engineering principles to biological systems to integrate mechanism with phenomenon and, importantly, to revise clinical practice. This study will review the existing applications of TSB in the areas of inflammation and wound healing, relate them to specific areas of interest to the burn community, and present an integrated framework that links TSB with traditional burn research.