Haplotypes of the interleukin 7 receptor alpha gene are correlated with altered expression in whole blood cells in multiple sclerosis
Haplotypes of the interleukin 7 receptor alpha gene are correlated with altered expression in whole blood cells in multiple sclerosis
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DOI：
10.1038/sj.gene.6364436
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发表时间：
2008-01-01
影响因子：
5
通讯作者：
Booth, D. R.
中科院分区：
文献类型：
--
作者：
McKay, F. C.;Swain, L. I.;Booth, D. R.
IL 7调节T细胞存活、分化和增殖。其受体CD127的α链是多态性的，并且其单倍型与移植恢复和自身免疫性疾病多发性硬化（MS），特别是原发性进行性MS（PPMS）相关。我们证明，两种CD127单倍型与编码可溶性CD127亚型的mRNA的比例高度相关（P
IL7 regulates T cell survival, differentiation and proliferation. The alpha chain of its receptor, CD127, is polymorphic, and its haplotypes are associated with recovery from transplantation and with the autoimmune disease multiple sclerosis (MS), especially primary progressive MS (PPMS). We demonstrate that two CD127 haplotypes are highly associated with the proportion of the mRNA encoding the soluble isoform of CD127 (P