Dissolution patterns of biocompatible glasses in 2-amino-2-hydroxymethyl-propane-1,3-diol (Tris) buffer
Dissolution patterns of biocompatible glasses in 2-amino-2-hydroxymethyl-propane-1,3-diol (Tris) buffer
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DOI：
10.1016/j.actbio.2012.08.051
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发表时间：
2013-02-01
影响因子：
9.7
通讯作者：
Hupa, M.
中科院分区：
文献类型：
--
作者：
Fagerlund, S.;Hupa, L.;Hupa, M.
一个连续流动测量系统与敏感的在线离子分析已被应用于研究的初始溶解行为的生物相容性玻璃在三羟甲基氨基甲烷。共研究了16种成分变化很大的玻璃。测量系统允许定量测定在与Tris溶液接触的前10-15分钟期间钠、钾、钙、镁、硅和磷的时间依赖性溶解速率。不同离子的溶解速率显示出显着的玻璃玻璃的变化，但所有的玻璃研究显示出四个不同的溶解模式之一。暴露1000 s后的离子溶解速率（表示为归一化的表面比质量损失速率）与文献中模型预测的玻璃的体外和体内反应性进行比较。结果表明，玻璃在Tris中的溶解速率与通过其他不同方法测量的它们的反应性之间存在明显的相关性。因此，测得的短期溶解模式可用于确定哪些玻璃适合作为医疗器械的生物活性、生物可降解或惰性生物材料。(C)2012 Acta Materialia Inc.由爱思唯尔有限公司出版。保留所有权利。
A continuous flow measurement system with sensitive on-line ion analysis has been applied to study the initial dissolution behaviour of biocompatible glasses in Tris. Altogether 16 glasses with widely varying compositions were studied. The measurement system allowed for quantitative determination of the time-dependent rates of dissolution of sodium, potassium, calcium, magnesium, silicon and phosphorus during the first 10-15 min in contact with Tris solution. The dissolution rates of the different ions showed significant glass to glass variations, but all glasses studied showed one of four distinct dissolution patterns. The ion dissolution rates after an exposure of 1000 s, expressed as the normalized surface-specific mass loss rates, were compared with the in vitro and in vivo reactivity of the glasses as predicted by models in the literature. The results showed a clear correlation between the dissolution rates of the glasses in Tris and their reactivity as measured by other different methods. Consequently, the measured short-term dissolution patterns could be used to determine which glasses are suitable as bioactive, biodegradable, or inert biomaterials for medical devices. (C) 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.