W-doped TiO2 nanoparticles with strong absorption in the NIR-II window for photoacoustic/CT dual-modal imaging and synergistic thermoradiotherapy of tumors
W-doped TiO2 nanoparticles with strong absorption in the NIR-II window for photoacoustic/CT dual-modal imaging and synergistic thermoradiotherapy of tumors
复制标题
W掺杂TiO2纳米粒子在NIR-II窗口中具有强吸收，用于肿瘤的光声/CT双模态成像和协同热放射治疗
DOI：
10.7150/thno.33574
复制
发表时间：
2019-01-01
期刊：
影响因子：
12.4
通讯作者：
Li, Wanwan
中科院分区：
文献类型：
--
作者：
Gao, Ke;Tu, Wenzhi;Li, Wanwan
具有综合诊断和治疗功能、低毒性、可通过联合治疗提高治疗效果的多功能纳米材料引起了人们的广泛关注。本文报道了一种新开发的多功能治疗剂——聚乙二醇化w掺杂TiO2纳米粒子（NPs），通过简单的有机途径合成，结果表明，由于成功掺杂w，这些聚乙二醇化的WTO纳米粒子在第二个近红外窗口（NIR-II）具有很强的吸光度，这些聚乙二醇化的WTO纳米粒子既可以吸收NIR-II激光，也可以吸收电离辐射。使它们非常适合用于肿瘤的双峰计算机断层扫描/NIR-II光声成像和协同NIR-II光热/放射治疗。此外，长期体内研究表明，这些聚乙二醇化的WTO NPs对小鼠体内无明显毒性，30天后可被清除。综上所述，该多功能治疗剂可同时吸收NIR-II激光和电离辐射，毒性可忽略，清除速度快，因此在生物医学成像和治疗方面具有很大的应用前景。
Multifunctional nanomaterials that have integrated diagnostic and therapeutic functions and low toxicity, and can enhance treatment efficacy through combination therapy have drawn tremendous amounts of attention. Herein, a newly developed multifunctional theranostic agent is reported, which is PEGylated W-doped TiO2 (WTO) nanoparticles (NPs) synthesized via a facile organic route, and the results demonstrated strong absorbance of these WTO NPs in the second near-infrared (NIR-II) window due to successful doping with W. These PEGylated WTO NPs can absorb both NIR-II laser and ionizing radiation, rendering them well suited for dual-modal computed tomography/NIR-II photoacoustic imaging and synergistic NIR-II photothermal/radiotherapy of tumors. In addition, the long-term in vivo studies indicated that these PEGylated WTO NPs had no obvious toxicity on mice in vivo, and they can be cleared after a 30-day period. In summary, this multifunctional theranostic agent can absorb both NIR-II laser and ionizing radiation with negligible toxicity and rapid clearance, therefore it has great promise for applications in imaging and therapeutics in biomedicine.