Relation between nocturnal decline in blood pressure and mortality - The Ohasama study
Relation between nocturnal decline in blood pressure and mortality - The Ohasama study
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DOI：
10.1016/s0895-7061(97)00274-4
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发表时间：
1997-11-01
影响因子：
3.2
通讯作者：
Hisamichi, S
中科院分区：
文献类型：
--
作者：
Ohkubo, T;Imai, Y;Hisamichi, S
为了研究夜间血压下降与死亡率的关系，我们测量了日本农村社区1542名40岁以上居民的动态血压。受试者平均随访5.1年，然后根据夜间血压下降的百分比被细分为四组：1)极端勺型：夜间血压下降大于或等于白天血压的20%；2)勺型：下降大于或等于10%，但不是20%；3)非勺型：下降大于或等于0%，但不下降10%；和4)勺型：不下降。通过COX比例风险回归模型检验夜间血压下降与死亡率之间的关系，该模型对年龄、性别、吸烟状况、既往心血管疾病病史和降压药物的使用进行了调整。倒勺子的死亡风险最高，其次是非勺子的。极端的勺子和勺子的死亡率没有差异。在接受治疗和未接受治疗的受试者中都观察到了这种关系，在心血管疾病死亡率方面比非心血管疾病死亡率方面更为明显，并且在对24小时、白天和夜间血压水平进行调整后没有改变。(C)1997年美国高血压杂志有限公司。
To investigate the relation between nocturnal decline in blood pressure and mortality, we obtained ambulatory blood pressures in 1542 residents aged 40 years or over of a rural Japanese community. Subjects were followed-up for a mean of 5.1 years and were then subdivided into four groups according to the percent decline in nocturnal blood pressure: 1) extreme dippers: percent decline in nocturnal blood pressure greater than or equal to 20% of the daytime blood pressure; 2) dippers: decline of greater than or equal to 10% but < 20%; 3) nondippers: decline of greater than or equal to 0% but < 10%; and 4) inverted dippers: no decline. The relationship between the decline in nocturnal blood pressure and mortality was examined by the Cox proportional hazards regression model adjusted for age, sex, smoking status, previous history of cardiovascular disease, and the use of antihypertensive medication. The mortality risk was highest in inverted dippers, followed by nondippers. There was no difference in mortality between extreme dippers and dippers. This relationship was observed for both treated and untreated subjects, was more pronounced for cardiovascular than for noncardiovascular mortality, and did not change after the data were adjusted for 24-h, daytime, and nighttime blood pressure levels. (C) 1997 American Journal of Hypertension, Ltd.