APLASTIC ANAEMIA IN SUBLETHALLY IRRADIATED MICE GIVEN ALLOGENEIC LYMPH NODE CELLS
APLASTIC ANAEMIA IN SUBLETHALLY IRRADIATED MICE GIVEN ALLOGENEIC LYMPH NODE CELLS
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DOI：
10.1111/j.1365-2141.1967.tb00758.x
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发表时间：
1967-01-01
影响因子：
6.5
通讯作者：
MOLE, RH
中科院分区：
文献类型：
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作者：
BARNES, DWH;MOLE, RH
将CoH/H小鼠的1000万个淋巴结细胞静脉注射到CBA/H小鼠体内，在450或600拉德亚致死暴露后的第二天，约有1/2的小鼠发生了致命的再生障碍性贫血。13 - 142天之间发生贫血死亡，很少有通常接受的移植物-宿主反应迹象。骨髓是可再生的。600 rd后的血液学和组织学观察以及较高中致死剂量和C3H或CBA混合淋巴结或骨髓细胞的实验表明，异体淋巴结细胞特异性地阻止了宿主型骨髓的再生。这一结果可能说明免疫功能细胞的体细胞突变是如何导致人类偶发再生障碍性贫血的。
When 10,000,000 lymph node cells from CoH/H mice were injected intravenously into CBA/H mice on the day after a sublethal exposure to 450 or 600 rads, about 1/2 the mice developed a fatal aplastic anemia. Deaths from anemia occurred between 13 and 142 days later with few of the ordinarily accepted signs of a graft-host reaction. The marrow was grossly aplastic. Hematologi-cal and histological observations after 600 rads and experiments with higher midlethal radiation doses and mixtures of C3H or CBA lymph node or bone marrow cells showed that the allogeneic lymph node cells specifically prevented regeneration of host-type bone marrow. The results may indicate how somatic mutation in immunologically competent cells could result in the sporadic occurrence of aplastic anemia in man.