PLASMA BRAIN NATRIURETIC PEPTIDE AND ATRIAL-NATRIURETIC-PEPTIDE CONCENTRATIONS CORRELATE WITH LEFT-VENTRICULAR END-DIASTOLIC PRESSURE
PLASMA BRAIN NATRIURETIC PEPTIDE AND ATRIAL-NATRIURETIC-PEPTIDE CONCENTRATIONS CORRELATE WITH LEFT-VENTRICULAR END-DIASTOLIC PRESSURE
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DOI：
10.1002/clc.4960160708
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发表时间：
1993-07-01
影响因子：
2.7
通讯作者：
GRUNERT, A
中科院分区：
文献类型：
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作者：
HAUG, C;METZELE, A;GRUNERT, A
本研究旨在探讨血浆脑利钠肽(BNP)和心钠素(ANP)浓度与左心室舒张末压(LVEDP)、肺毛细血管楔压(PCWP)、舒张期肺动脉压(DPAP)、右房压(RAP)和射血分数(EF)之间的关系。应用放射免疫法测定85例诊断心导管置入术患者Sep Pak C18拔管后的血浆BNP和ANP水平。数据采用线性和非线性回归分析及配对样本t检验。血浆BNP、ANP水平与LVEDP呈非线性相关(BNP：r=0.94p<；0.001；ANP：r=0.81p<；0.001)，与PCWP、DPAP、RAP呈显著线性相关，与EF呈显著负相关。心钠素浓度从肺动脉到左心室、从左心室到股静脉均显著降低(p<；0.001)。左心室和股静脉的脑钠素水平也显著降低(p<；0.001)，但肺动脉和左心室的脑钠素水平没有显著差异。脑钠素和心钠素浓度在肺动脉血和左室血之间呈显著正相关(r=0.99，r=0.93p<；0.001)，在左心室和外周血之间也呈显著正相关(r=0.99，r=0.94p<；0.001)。提示外周血浆BNP和ANP水平是反映心功能的有用的无创性指标。
The present study was designed to investigate whether brain natriuretic peptide (BNP) and atrial natriuretic peptide (ANP) plasma concentrations correlate with left ventricular end-diastolic pressure (LVEDP), pulmonary capillary wedge pressure, (PCWP), diastolic pulmonary arterial pressure (DPAP), right atrial pressure (RAP), or ejection fraction (EF). Plasma BNP and ANP levels were determined by commercial radioimmunoassays (Peninsula) after Sep Pak C18 extraction in blood samples withdrawn from the pulmonary artery and the left ventricle or from the left ventricle and the femoral vein in 85 patients undergoing diagnostic cardiac catheterization. Linear and nonlinear regression analysis and the paired sample t-test were applied to the data. Pulmonary arterial plasma BNP and ANP levels showed a close nonlinear correlation with LVEDP (BNP: r = 0.94, p < 0.001; ANP: r = 0.81, p < 0.001), a significant linear correlation with PCWP, DPAP, and RAP, and a significant negative correlation with EF. ANP concentrations decreased significantly from the pulmonary artery to the left ventricle and from the left ventricle to the femoral vein (p < 0.001). BNP levels also decreased significantly between the left ventricle and the femoral vein (p < 0.001), but there was no significant difference between pulmonary arterial and left ventricular BNP concentrations. BNP and ANP concentrations correlated significantly between pulmonary arterial and left ventricular blood samples (BNP: r = 0.99, ANP: r = 0.93, p < 0.001) and between left ventricular and peripheral blood samples (BNP:r = 0.99, ANP: r = 0.94, p < 0.001). The present data suggest that peripheral plasma BNP and ANP levels are useful noninvasive indices of cardiac performance.