Association between diet, lifestyle, metabolic cardiovascular risk factors, and plasma C-reactive protein levels
Association between diet, lifestyle, metabolic cardiovascular risk factors, and plasma C-reactive protein levels
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DOI：
10.1016/j.metabol.2004.06.010
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发表时间：
2004-11-01
影响因子：
9.8
通讯作者：
Nilsson, J
中科院分区：
文献类型：
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作者：
Fredrikson, GN;Hedblad, B;Nilsson, J
C反应蛋白(CRP)水平升高与代谢综合征的几个组成部分有关，但饮食和生活方式因素对CRP水平的直接影响在很大程度上仍不清楚。本研究的目的是探讨C反应蛋白与饮食和生活方式因素的关系。采用高灵敏度的酶联免疫吸附试验(ELISA法)测定了760名参加β-阻滞剂降胆固醇无症状性斑块研究(BCAPS)的受试者的血浆CRP水平。根据先前的研究结果，C反应蛋白水平升高与高体重指数(BMI)(P=.012)、甘油三酯(P=.001)、收缩压(P=.019)、胆固醇/高密度脂蛋白(P=.009)和低高密度脂蛋白(P=.001)相关。在吸烟者(P=.023)和维生素C摄入量低的受试者(P=.018)中，CRP也升高。当将男性和女性放在一起分析时，C反应蛋白与总卡路里、总脂肪、饱和脂肪、单不饱和脂肪、多不饱和脂肪、n-3多不饱和脂肪酸、n-6多不饱和脂肪酸、纤维、维生素E、胡萝卜素或硒的饮食摄入量或体力活动没有显著相关性。而在女性亚组中，CRP与总脂肪(r=-0.13，P=0.011)、饱和脂肪(r=-0.13，P=0.011)、单不饱和脂肪(r=-0.13，P=0.010)、多不饱和脂肪(r=-0.14，P=0.007)和n-3多不饱和脂肪酸(r=-0.14，P=0.004)的摄入量呈弱负相关。对吸烟、肥胖和能量不足亚组的分层因素分析在很大程度上证实了这一结果，尽管在从不吸烟的男性中，高纤维维生素C/β胡萝卜素摄入量与低CRP水平相关。这些观察表明，C反应蛋白水平与个人饮食和生活方式因素只有微弱的联系。令人惊讶的是，在女性中，较高的脂肪摄入量往往与较低的CRP值相关。(C)2004 Elsevier Inc.保留所有权利。
Increased C-reactive protein (CRP) levels have been associated with several of the components of the metabolic syndrome, but the direct influence of diet and lifestyle factors on CRP levels remains largely unknown. The purpose of the present study was to investigate the association between CRP and diet and lifestyle factors. Plasma CRP levels were determined by a highly sensitive enzyme-linked immunosorbent assay (ELISA) in 760 participants in the beta-Blocker Cholesterol-Lowering Asymptomatic Plaque Study (BCAPS). In accordance with previous findings, increased levels of CRP were associated with high body mass index (BMI) (P = .012), triglycerides (P = .001), systolic blood pressure (P = .019), cholesterol/high-density lipoprotein (HDL) ratio (P = .009), and low HDL cholesterol (P = .001). CRP was also increased in smokers (P = .023) and in subjects with a low vitamin C intake (P = .018). When men and women were analyzed together, there were no significant associations between CRP and dietary intake of total calories, total fat, saturated fat, monounsaturated fat, polyunsaturated fat, n-3 polyunsaturated fatty acids, n-6 polyunsaturated fatty acids, fiber, vitamin E, carotene, or selen, or in physical activity. However, in the female subgroup weak inverse relations were observed between CRP and the intake of total fat (r = -0.13, P = .011), saturated fat (r = -0.13, P = .011), monounsaturated fat (r = -0.13, P =.010), polyunsaturated fat (r = -0.14, P = .007), and n-3 PUFA (r = -0.14, P = .004). Stratified factor analyses in smoking subgroups, obese, and in under-reporters of energy, largely confirmed the results although in male never-smokers a combination of high fiber vitamin C/beta carotene intake was associated with low CRP levels. These observations suggest that CRP levels are only marginally associated with individual dietary and lifestyle factors. Surprisingly, a higher intake of fat tended to be associated with lower CRP values among women. (C) 2004 Elsevier Inc. All rights reserved.