Optimal clinical management of children receiving dietary therapies for epilepsy: Updated recommendations of the International Ketogenic Diet Study Group.
Optimal clinical management of children receiving dietary therapies for epilepsy: Updated recommendations of the International Ketogenic Diet Study Group.
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DOI：
10.1002/epi4.12225
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发表时间：
2018-06
期刊：
影响因子：
3
通讯作者：
Practice Committee of the Child Neurology Society
中科院分区：
文献类型：
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作者：
Kossoff EH;Zupec-Kania BA;Auvin S;Ballaban-Gil KR;Christina Bergqvist AG;Blackford R;Buchhalter JR;Caraballo RH;Cross JH;Dahlin MG;Donner EJ;Guzel O;Jehle RS;Klepper J;Kang HC;Lambrechts DA;Liu YMC;Nathan JK;Nordli DR Jr;Pfeifer HH;Rho JM;Scheffer IE;Sharma S;Stafstrom CE;Thiele EA;Turner Z;Vaccarezza MM;van der Louw EJTM;Veggiotti P;Wheless JW;Wirrell EC;Charlie Foundation;Matthew's Friends;Practice Committee of the Child Neurology Society
生酮饮食疗法（KDTs）是治疗儿童难治性癫痫的有效非药物治疗方法。多年来，由于缺乏一致的协议，KDT在世界各地的实施方式各不相同。2009年，发表了一份关于KDT儿童管理的专家共识指南，重点关注患者选择，KDT前咨询和评估，饮食选择和属性，实施，补充，随访，副作用和KDT停药。它有助于概述最先进的方案，标准化多中心临床试验的KDT，并确定未来研究的争议和不确定性领域。十年后的今天，本指南的组织者和作者与其他作者一起提出了修订版，以纳入最近的研究，特别是关于其他饮食治疗，澄清使用适应症，开始和持续使用期间的副作用，补充剂的价值以及KDT停药的方法。此外，作者完成了一项关于其机构实践的调查，并将其与原始共识调查的答复进行了比较，以显示过去10年的管理趋势。
Ketogenic dietary therapies (KDTs) are established, effective nonpharmacologic treatments for intractable childhood epilepsy. For many years KDTs were implemented differently throughout the world due to lack of consistent protocols. In 2009, an expert consensus guideline for the management of children on KDT was published, focusing on topics of patient selection, pre‐KDT counseling and evaluation, diet choice and attributes, implementation, supplementation, follow‐up, side events, and KDT discontinuation. It has been helpful in outlining a state‐of‐the‐art protocol, standardizing KDT for multicenter clinical trials, and identifying areas of controversy and uncertainty for future research. Now one decade later, the organizers and authors of this guideline present a revised version with additional authors, in order to include recent research, especially regarding other dietary treatments, clarifying indications for use, side effects during initiation and ongoing use, value of supplements, and methods of KDT discontinuation. In addition, authors completed a survey of their institution's practices, which was compared to responses from the original consensus survey, to show trends in management over the last 10 years.