In vivo assessment of left ventricular wall and chamber dynamics during transient myocardial ischemia using cine computed tomography.
In vivo assessment of left ventricular wall and chamber dynamics during transient myocardial ischemia using cine computed tomography.
复制标题
使用电影计算机断层扫描对短暂性心肌缺血期间左心室壁和心室动力学进行体内评估。
DOI：
10.1016/0002-9149(85)90247-4
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
D. Boyd
中科院分区：
文献类型：
--
作者：
D. Farmer;M. Lipton;C. Higgins;H. Ringertz;P. Dean;R. Sievers;D. Boyd
采用一种新型的计算机断层扫描（CT）设计，采用快速移动的聚焦电子束，同时在2个轴向水平上对6只狗的心脏进行50毫秒的CT扫描，以分析急性左冠状动脉前降支（LAD）闭塞后左室（LV）壁厚和横截面面积。静息时静脉注射造影剂时，左室急性闭塞后60秒，闭塞解除后60秒，在1秒内（电影获取）进行10或15次50毫秒CT扫描（17次扫描/秒），通过左室中部。对照组可能缺血的前段收缩壁增厚的百分比为37±15%（±标准差），LAD闭塞时为- 5±6.5% （p < 0.01）。控制状态下左室管腔面积从舒张末期到收缩期末期的变化百分比（50±19%）与LAD闭塞状态（47±21%）相比无显著差异。对照组与解除闭塞后60秒收缩壁增厚程度及左室管腔面积无显著差异。急性缺血时局部心肌功能的改变表现为受损节段收缩期壁变薄，整体左室功能无明显改变。这些特征可以通过电影计算机断层扫描在孤立的心脏周期评估。
Using a new computed tomographic (CT) scanner design that uses a rapidly moving focused electron beam, 50-ms CT scans were obtained at 2 axial levels simultaneously through the hearts of 6 dogs in order to analyze left ventricular (LV) wall thickness and cross-sectional chamber area after acute occlusion of the left anterior descending coronary artery (LAD). Ten or fifteen 50-ms CT scans (rate of 17 scans/s) through the middle of the left ventricle were performed in 1 second (cine acquisition) during intravenous administration of contrast medium at rest, 60 seconds after acute occlusion of the LAD, and 60 seconds after release of the occlusion. The percent extent of systolic wall thickening of the potentially ischemic anterior segment was 37 ± 15% (± standard deviation) in the control state and −5 ± 6.5% during LAD occlusion (p < 0.01). There was no significant difference in the percent change in LV luminal area from end-diastole to end-systole between the control state (50 ± 19%) compared with LAD occlusion (47 ± 21%). There were no significant differences in the extent of systolic wall thickening or LV luminal area between the control state and 60 seconds after release of occlusion. The alterations in regional myocardial function during acute ischemia are characterized by wall thinning during systole in the jeopardized segment and no significant change in global LV function. These features can be assessed by cine computed tomography during a solitary heart cycle.