Dual midbrain and forebrain origins of thalamic inhibitory interneurons.
Dual midbrain and forebrain origins of thalamic inhibitory interneurons.
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DOI：
10.7554/elife.59272
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发表时间：
2021-02-01
期刊：
影响因子：
7.7
通讯作者：
Delogu A
中科院分区：
文献类型：
--
作者：
Jager P;Moore G;Calpin P;Durmishi X;Salgarella I;Menage L;Kita Y;Wang Y;Kim DW;Blackshaw S;Schultz SR;Brickley S;Shimogori T;Delogu A
灵长类动物丘脑中普遍存在抑制性中间神经元，这与小鼠的中间神经元稀少形成了鲜明对比。在这里，我们发现了一个比预期更大的复杂性和分布在小鼠丘脑的中间神经元，其中所有的丘脑中间神经元都可以追溯到两个发育计划：一个在中脑，另一个在前脑。中间神经元根据其来源而迁移到功能不同的丘脑皮质核团：丰富的中脑来源的类别分布在第一级和更高级别的感觉丘脑中，而较罕见的前脑产生的类别仅限于一些更高级别的关联区。我们还观察到，中脑出生类的标志物在新大陆猴的丘脑中大量表达。因此，这些数据表明，尽管哺乳动物物种间神经元密度存在广泛差异，但大脑较大的哺乳动物丘脑间神经元个体发育组织的蓝图是存在的，并且可以在小鼠身上进行研究。
The ubiquitous presence of inhibitory interneurons in the thalamus of primates contrasts with the sparsity of interneurons reported in mice. Here, we identify a larger than expected complexity and distribution of interneurons across the mouse thalamus, where all thalamic interneurons can be traced back to two developmental programmes: one specified in the midbrain and the other in the forebrain. Interneurons migrate to functionally distinct thalamocortical nuclei depending on their origin: the abundant, midbrain-derived class populates the first and higher order sensory thalamus while the rarer, forebrain-generated class is restricted to some higher order associative regions. We also observe that markers for the midbrain-born class are abundantly expressed throughout the thalamus of the New World monkey marmoset. These data therefore reveal that, despite the broad variability in interneuron density across mammalian species, the blueprint of the ontogenetic organisation of thalamic interneurons of larger-brained mammals exists and can be studied in mice.