Improvement in β-cell function after diet-induced weight loss is associated with decrease in pancreatic polypeptide in subjects with type 2 diabetes
Improvement in β-cell function after diet-induced weight loss is associated with decrease in pancreatic polypeptide in subjects with type 2 diabetes
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DOI：
10.1016/j.jdiacomp.2012.05.003
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发表时间：
2012-09-01
影响因子：
3
通讯作者：
Pelikanova, T.
中科院分区：
文献类型：
--
作者：
Kahleova, H.;Mari, A.;Pelikanova, T.
目的：方法：对74例T2 D患者进行为期24周的生活方式干预，其中12周为减肥饮食（-500 kcal/d），12周为减肥饮食+有氧运动。所有受试者在第0、12和24周进行检查。在标准膳食试验期间评估β细胞功能。通过C肽去卷积计算胰岛素分泌率（ISR），并用数学模型定量β细胞功能。在空腹状态和高胰岛素异糖钳夹诱导的高胰岛素血症期间测定血浆胃肠肽浓度。
Objective: The aim of our study was to evaluate the effect of a lifestyle intervention program on beta-cell function and to explore the role of gastrointestinal peptides in subjects with T2D.Methods: Subjects with T2D (n = 74) received 24 weeks of intervention: 12 weeks of slimming diet (-500 kcal/day) and the subsequent 12 weeks of diet were combined with aerobic exercise. All subjects were examined at weeks 0, 12 and 24. beta-cell function was assessed during standard meal tests. Insulin secretory rate (ISR) was calculated by C-peptide deconvolution, and beta-cell function was quantified with a mathematical model. Plasma concentrations of gastrointestinal peptides were measured in a fasting state and during hyperinsulinemia induced by hyperinsulinemic isoglycemic clamp.Results: Mean weight loss was 5.03 +/- 4.38 kg (p