Differential effect of environment enrichment and social isolation on depressive-like behavior, spontaneous activity and serotonin and norepinephrine concentration in prefrontal cortex and ventral striatum
Differential effect of environment enrichment and social isolation on depressive-like behavior, spontaneous activity and serotonin and norepinephrine concentration in prefrontal cortex and ventral striatum
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DOI：
10.1016/j.pbb.2007.11.004
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发表时间：
2008-03-01
影响因子：
3.6
通讯作者：
Fornaguera, Jaime
中科院分区：
文献类型：
--
作者：
Brenes, Juan C.;Rodriguez, Odir;Fornaguera, Jaime
为了确定出生后环境对一些行为和神经化学类抑郁参数的影响，将同窝的斯普拉格 - 道利大鼠从断奶起分别在社会隔离、标准实验室条件或环境丰富三种环境中饲养。在出生后第37、65、93和107天评估其旷场活动，并在最后一次旷场测试前1小时进行强迫游泳测试。行为测试后，分析其前额叶皮质和腹侧纹状体中的单胺浓度。与对照组和隔离饲养组相比，环境丰富组降低了旷场活动，产生了抗抑郁样效果，并增加了前额叶皮质中的血清素浓度。另一方面，社会隔离不影响旷场活动，但增加了类抑郁行为，并降低了腹侧纹状体中去甲肾上腺素的含量。饲养条件引起的这些神经化学变化与强迫游泳测试中的行为表现相关。此外，即使从饲养的第一周起，运动活动也可预测静止行为。总体而言，早期饲养过程中物理和社会环境的特定变化会导致一些行为和神经化学改变，这可能对理解神经发育和经验因素在人类抑郁症中可能起的作用具有相关性。（c）2007爱思唯尔公司。保留所有权利。
In order to determine the effect of postnatal environments on some behavioral and neurochemical depressive-like parameters, mate Sprague-Dawley rats were reared from weaning in either social isolation, standard laboratory conditions, or environmental enrichment. Open-field activity was assessed at postnatal days 37, 65, 93 and 107 and I h before the last open-field test, a forced-swimming test was carried out. After behavioral tests, the monoamines concentrations were analyzed in prefrontal cortex and ventral striatum. Relative to control and isolation rearing, the environmental enrichment reduced open-field activity, led to antidepressive-like effects and increased serotonin concentrations in the prefrontal cortex. Social isolation, on the other hand, did not affect open-field activity, but increased depressive-like behavior and reduced the amount of norepinephrine in the ventral striatum. Those neurochemical changes induced by rearing conditions correlated with the behavioral performance in the forced-swimming test. Also, immobility behavior could be predicted by locomotor activity even from the first week of housing. Overall, specific variations in physical and social environment during early rearing lead to some behavioral and neurochemical alterations which might be relevant for understanding the role that neurodevelopmental and experiential factors could have in human depression. (c) 2007 Elsevier Inc. All rights reserved.