Theophylline analysis at the chest clinic--comparison of a portable versus conventional system.
Theophylline analysis at the chest clinic--comparison of a portable versus conventional system.
复制标题
胸部诊所的茶碱分析——便携式系统与传统系统的比较。
DOI：
10.1016/s0954-6111(06)80206-4
复制
发表时间：
1991
影响因子：
4.3
通讯作者：
A. D. Mackay
中科院分区：
文献类型：
--
作者：
D. R. Baldwin;J. D. Berg;B. Buckley;A. D. Mackay
通过在两个平行的胸科诊所研究这两种方法，比较了一种新的、便携式、直接进样、高效液相色谱仪测量茶碱与传统的实验室分析的运行成本和临床应用。36例患者采用便携式方法进行管理，33例采用传统系统进行管理。他们已经接受茶碱制剂治疗哮喘或慢性气流限制。在12周的研究期间，两家诊所中浓度在治疗范围内的患者百分比从33%上升到约87%，但使用便携式系统仅在6周内就实现了这一变化。茶碱水平升高至治疗范围的患者通过视觉模拟量表测量的症状评分有所改善，但我们无法证明肺量测定法有任何显着变化。便携式系统的成本与实验室分析相比是有利的，并且具有更快地检测不遵守规定的情况以及在咨询时与患者进行讨论的便利的额外好处。
The running cost and clinical application of a new, portable, direct-injection, high-performance, liquid chromatograph for the measurement of theophylline was compared with conventional laboratory-based analysis by studying the two methods in two parallel chest clinics. Thirty-six patients were managed with the portable method and 33 by the conventional system. They were already receiving theophylline preparations for treatment of their asthma or chronic airflow limitation. Over the 12-week period of study, the percentage of patients with levels in the therapeutic range rose from 33% to approximately 87% in both clinics, but this change was achieved in only 6 weeks using the portable system. Patients whose theophylline levels were increased into the therapeutic range had improved symptom scores as measured by visual analogue scales but we were unable to demonstrate any significant change in spirometry. The cost of the portable system compared favourably with laboratory analysis, and had the additional benefit of quicker detection of non-compliance and facility for discussion with the patients at the time of consultation.