All-trans-retinoic acid ameliorated high fat diet-induced atherosclerosis in rabbits by inhibiting platelet activation and inflammation.
All-trans-retinoic acid ameliorated high fat diet-induced atherosclerosis in rabbits by inhibiting platelet activation and inflammation.
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全反式视黄酸通过抑制血小板活化和炎症改善高脂饮食引起的兔动脉粥样硬化
DOI：
10.1155/2012/259693
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发表时间：
2012
影响因子：
--
通讯作者：
Wang Y
中科院分区：
文献类型：
--
作者：
Zhou B;Pan Y;Hu Z;Wang X;Han J;Zhou Q;Zhai Z;Wang Y
背景。全反式维甲酸（atRA）对许多增殖性疾病有效。我们研究了 atRA 对动脉粥样硬化的保护作用。方法。兔子被随机分配接受基础饮食或 HFD，为期 4 周。 HFD 组随后在接下来的 8 周内分别接受瑞舒伐他汀（3mg/天）、atRA（5mg/kg/天）或相同体积的赋形剂。结果。 HFD 组显示血浆脂质和主动脉斑块形成增加。 P-选择素表达和纤维蛋白原在血小板上的结合或在主动脉内膜上的沉积也显着增加，血浆中 TNF-α、IL-6 和纤维蛋白原的水平也显着增加。 atRA治疗8周后，血脂显着下降，主动脉病变得到改善。 AtRA 还抑制 P-选择素和纤维蛋白原在血小板上的表达以及在主动脉内膜上的沉积。结论。 AtRA 可以通过抑制血小板活化和炎症来改善 HFD 诱导的兔 AS。
Background. All-trans-retinoic acid (atRA) is effective for many proliferative diseases. We investigated the protective effects of atRA against atherosclerosis. Methods. Rabbits were randomly allocated to receive basal diet or an HFD for 4 weeks. HFD group then received rosuvastatin (3 mg/day), atRA (5 mg/kg/day), or the same volume of vehicle, respectively, for next 8 weeks. Results. HFD group showed increases in plasma lipids and aortic plaque formation. P-selectin expression and fibrinogen binding on platelets or deposition on the intima of the aorta also increased significantly as did the levels of TNF-α, IL-6, and fibrinogen in plasma. After 8 weeks of treatment with atRA, there was a significant decrease in plasma lipids and improvement in aortic lesions. AtRA also inhibited the expression of P-selectin and fibrinogen binding on platelets and deposition on the intima of the aorta. Conclusion. AtRA can ameliorate HFD-induced AS in rabbits by inhibiting platelet activation and inflammation.
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