Endothelial signaling during development
Endothelial signaling during development
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DOI：
10.1038/nm0603-661
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发表时间：
2003-06-01
期刊：
影响因子：
82.9
通讯作者：
Melton, DA
中科院分区：
文献类型：
--
作者：
Cleaver, O;Melton, DA
血管灌注体内所有组织，并介导组织和血液之间的重要代谢交换。然而，越来越多的证据表明，在胚胎发育和细胞分化过程中，血管细胞和周围靶器官细胞之间的旁分泌信号转导发挥着直接作用。了解这种信号传导的性质及其在胚胎和成人组织中的异质性，不仅可以深入了解正常发育细胞命运决定的机制，还可以为心脏病、糖尿病或癌症等多种疾病提供新的靶向治疗方法。
Blood vessels perfuse all tissues in the body and mediate vital metabolic exchange between tissues and blood. Increasing evidence, however, points to a direct role for paracrine signaling between blood vessel cells and surrounding target organ cells, during embryonic development and cell differentiation. Understanding the nature of this signaling and its heterogeneity, both in the embryo and in adult tissues, may not only provide insights into mechanisms for normal developmental cell fate decisions, but could also lead to novel targeted therapeutic approaches for a variety of diseases such as heart disease, diabetes or cancer.