Fiber Bragg Grating Sensors-Based Thermometry of Gold Nanorod-Enhanced Photothermal Therapy in Tumor Model
Fiber Bragg Grating Sensors-Based Thermometry of Gold Nanorod-Enhanced Photothermal Therapy in Tumor Model
复制标题
基于光纤布拉格光栅传感器的金纳米棒增强光热治疗肿瘤模型的测温
DOI：
10.1109/jsen.2021.3082042
复制
发表时间：
2022-06-15
影响因子：
4.3
通讯作者：
Saccomandi, Paola
中科院分区：
文献类型：
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作者：
Bianchi, Leonardo;Mooney, Rachael;Saccomandi, Paola
这项工作提出了使用飞秒激光写入光纤布拉格光栅（FBG）传感器进行内部温度监测的肿瘤进行金纳米棒（AuNR）介导的光热治疗（PTT）。亚毫米光纤光栅阵列能够在小鼠皮下乳腺肿瘤内进行精确的准分布温度测量。此外，FBG允许研究暴露于940 nm和1064 nm辐射的癌组织上的激光-组织相互作用和AuNR辅助的光热增强。在1064 nm的情况下，与对照相比，引入肿瘤定位的AuNR导致平均温度变化总体增加13 ℃，而在940 nm的情况下，平均温度变化与6 ℃相似。这种传感解决方案允许在AuNR辅助的PTT下对内部肿瘤温度进行微创测量。该可行性研究为评估不同激光源下纳米颗粒介导的热结果奠定了基础。
This work proposes the use of femtosecond laser-written fiber Bragg grating (FBG) sensors for internal temperature monitoring of tumors undergoing gold nanorod (AuNR)-mediated photothermal therapy (PTT). Arrays of sub-millimetric FBGs enabled an accurate and quasidistributed temperature measurement within subcutaneous breast tumors in mice. Furthermore, FBGs permitted to investigate the laser-tissue interaction and AuNR-assisted photothermal enhancement on cancerous tissue exposed to 940 nm and 1064 nm radiations. The introduction of the tumorlocalized AuNRs resulted in an overall increase of 13 degrees C of the mean temperature change, compared to control, in case of 1064 nm, while similar to 6 degrees C in case of 940 nm. This sensing solution allows the minimally invasive measurement of the internal tumor temperature under AuNR-assisted PTT. This feasibility study sets the basis for the evaluation of the thermal outcome mediated by nanoparticles under different laser sources.