Cytokine levels in malignant ascites and peripheral blood of patients with advanced ovarian cancer
Cytokine levels in malignant ascites and peripheral blood of patients with advanced ovarian cancer
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DOI：
10.1055/s-2007-1022247
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发表时间：
1996-02-01
影响因子：
2.7
通讯作者：
Morenz, J
中科院分区：
文献类型：
--
作者：
Radke, J;Schmidt, D;Morenz, J
通过 ELISA 检测 14 名晚期卵巢癌（IV 期）患者的血液和腹水中各种细胞因子的浓度。对照组由 6 名患有良性妇科疾病的患者组成。与良性妇科疾病患者相比，卵巢癌患者腹水和/或血浆中IL-6、IL-8、IL-10、TNF-α和sIL-2R的水平显着升高。 IL-1α、IL-1β、IL-2、IFN-γ和sCD14水平没有增加。讨论了细胞因子在卵巢癌中可能的发病意义。
The concentrations of various cytokines were examined by ELISA in blood and in ascites from 14 patients with advanced ovarian cancer (stage IV). The control group consisted of 6 patients with benign gynaecological disorders. Compared with patients with benign gynaecological disorders, ascites and/or plasma of patients with ovarian cancer showed significantly higher levels of IL-6, IL-8, IL-10, TNF-alpha, and sIL-2R. There were no increases of IL-1 alpha, IL-1 beta, IL-2, IFN-gamma, and sCD14 levels. The possible pathogenetic significance of cytokines in ovarian cancer is discussed.