Cys-gly-cys tripeptide complexes of nickel: Binuclear analogues for the catalytic site in acetyl coenzyme A synthase
Cys-gly-cys tripeptide complexes of nickel: Binuclear analogues for the catalytic site in acetyl coenzyme A synthase
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DOI：
10.1021/ja038086u
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发表时间：
2004-04-14
影响因子：
15
通讯作者：
Riordan, CG
中科院分区：
文献类型：
--
作者：
Krishnan, R;Riordan, CG
三肽Ac−CysGlyCys−CONH2被用作配体，以与乙酰辅酶A合酶活性位点相同的方式结合Ni。Ni−肽构建体是制备通过桥接Cys侧链形成的较大结构的合适金属配体。配合物Ni（CysGlyCys）Ni（dppe）和Ni（CysGlyCys）Ni（depe）作为双核子簇的紧密结构表示，表现出易于进入结合CO的还原混合价Ni（II）Ni（I）状态的电化学性质。
The tripeptide, Ac−CysGlyCys−CONH2, is utilized as a ligand to bind Ni in a fashion identical to that found at the active site of acetyl coenzyme A synthase. The Ni−peptide construct is a suitable metalloligand for the preparation of larger structures formed via bridging Cys side chains. The complexes Ni(CysGlyCys)Ni(dppe) and Ni(CysGlyCys)Ni(depe) serve as close structural representations for the binuclear subcluster, exhibiting electrochemical properties that demonstrate facile access to the reduced mixed valent Ni(II)Ni(I) state, which binds CO.