How many sentinel nodes should be harvested in oral squamous cell carcinoma?
How many sentinel nodes should be harvested in oral squamous cell carcinoma?
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DOI：
10.1007/s00405-007-0548-x
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发表时间：
2008-07-01
影响因子：
2.6
通讯作者：
Soutar, David S.
中科院分区：
文献类型：
--
作者：
Atula, Timo;Shoaib, Taimur;Soutar, David S.
前哨淋巴结（SLN）活检时收获的淋巴结数量仍有争议。本研究的目的是检查用于组织病理学分析的最大收获淋巴结数量。我们还想确定SLN内的放射性水平或其大小是否是淋巴结转移可能性的指标。方法收集T1/T2 N 0期口腔癌和口咽癌患者颈淋巴结标本34例。共测量了76个SLN的放射性和淋巴结尺寸和体积。76个淋巴结中有16个（阳性淋巴结）发现肿瘤，其余60个淋巴结无肿瘤（阴性淋巴结）。16例中9例转移灶位于最热淋巴结。两名患者有一个以上的阳性前哨淋巴结：第一和第四最热的一个和第二和第四最热的节点在另一个包含肿瘤。然而，如果只取出最热的三个前哨淋巴结，所有患者都可以准确分期。含有肿瘤的淋巴结的最大直径大于非转移性SLN。为了准确地对颈部进行分期，只需要对三个最热的淋巴结进行采样。
The number of harvested lymph nodes when performing sentinel lymph node (SLN) biopsy remains controversial. The aim of this study was to examine the maximum number of nodes to be harvested for histopathological analysis. We also wanted to determine if the level of radioactivity within a SLN or its size were indicators for the likelihood of nodal metastases. The SLNs from 34 neck dissection specimens from patients with T1/T2 N0 oral and oropharyngeal carcinomas were included. Altogether 76 SLNs were measured for radioactivity and lymph node dimensions and volume. Tumour was identified in 16 of 76 nodes ( positive nodes), and the remaining 60 nodes were free from tumour ( negative nodes). In 9 of 16 cases, metastases were in the hottest node. Two patients had more than one positive SLN: the first and fourth hottest in one and the second and fourth hottest nodes in another contained tumour. However, all patients would have been staged accurately if only the hottest three sentinel nodes had been retrieved. Lymph nodes that contained tumour had a greater maximum diameter than non-metastatic SLNs. To stage the neck accurately, only the three hottest lymph nodes required sampling.