Rhodium‐Catalyzed [3+2]‐Annulation of ortho‐ Diazoquinones with Enol Ethers: Diversity‐Oriented Total Synthesis of Aflatoxin B 2
Rhodium‐Catalyzed [3+2]‐Annulation of ortho‐ Diazoquinones with Enol Ethers: Diversity‐Oriented Total Synthesis of Aflatoxin B 2
复制标题
铑催化[3 2]邻位重氮醌与烯醇醚的环化：黄曲霉毒素 B 2 的多样性定向全合成
DOI：
10.1002/ejoc.202100186
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发表时间：
2021
影响因子：
2.8
通讯作者：
Sharma, Indrajeet
中科院分区：
文献类型：
--
作者：
Paymode, Dinesh J.;Sharma, Indrajeet
通过Rh催化的邻重氮醌与烯醇醚的[3+2]-环化反应，发展了一种简单有效的合成取代和稠合多环2，3-二氢呋喃的方法。该方法底物范围广，已用于天然产物黄曲霉毒素B2的简明全合成。
A simple and efficient approach for synthesizing substituted and fused polycyclic 2,3‐dihydrobenzofurans has been developed through a Rh‐catalyzed [3+2]‐annulation ofortho‐diazoquinones with enol ethers. This methodology has a broad substrate scope and has been employed for the concise total synthesis of natural product aflatoxin B2.