Cortical depression in the mouse auditory cortex after sound discrimination learning
Cortical depression in the mouse auditory cortex after sound discrimination learning
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DOI：
10.1016/j.neures.2010.01.005
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发表时间：
2010-05-01
影响因子：
2.9
通讯作者：
Shibuki, Katsuei
中科院分区：
文献类型：
--
作者：
Ohshima, Shinsuke;Tsukano, Hiroaki;Shibuki, Katsuei
采用经颅黄蛋白荧光成像技术研究了小鼠辨音学习后的皮层反应。缺水小鼠被训练区分有奖励（S+）和无奖励（S-）声音刺激。学习结束后，他们被麻醉，并在右侧听觉皮层记录对S+和S-的皮层反应。以10 kHz纯音（PT）和10 kHz调幅（AM）作为S+和S-时，AM对S的皮质反应明显抑制，而PT对S-的皮质反应则不明显。皮质对S+的反应无明显变化。以5 kHz ~ 40 kHz的调频上箭头和40 kHz ~ 5 kHz的调频下箭头分别作为S+和S。学习后，皮质对调频上箭头和调频下箭头的S-的反应明显下降，而对S+的反应则没有变化。学习后左听皮层对S的反应无明显变化。FMs对S的学习性抑制在右侧初级听觉皮层40 kHz声位带内侧最为明显，该区域可能与FM声音加工有关。(C) 2010爱思唯尔爱尔兰有限公司和日本神经科学学会。版权所有。
Cortical responses after sound discrimination learning were investigated using transcranial flavoprotein fluorescence imaging in mice. Water-deprived mice were trained to discriminate between rewarded (S+) and unrewarded (S-) sound stimuli. After the learning, they were anesthetized, and cortical responses to S+ and S- were recorded in the right auditory cortex. When a pure tone (PT) at 10 kHz and a 10 kHz amplitude-modulated (AM) sound were used as S+ and S-, the cortical responses to S using AM were significantly depressed but those to S- using PT were not. The cortical responses to S+ showed no significant change. Upward frequency-modulated sounds from 5 kHz to 40 kHz (FM up arrow) and downward frequency-modulated sounds from 40 kHz to 5 kHz (FM down arrow) were also used as S+ and S. Cortical responses to S- using FM up arrow and FM down arrow were significantly depressed after learning, while those to S+ were unchanged. No significant change of cortical responses to S using FMs was observed in the left auditory cortex after learning. The learning-induced depression of S using FMs was most clearly observed in the medial part of the tonotopic band to 40 kHz in the right primary auditory cortex, which might be involved in processing FM sounds. (C) 2010 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.